HSP90-Tau Disaggregation Complex Enhancement

## **Molecular Mechanism and Rationale** The heat shock protein 90 (HSP90) chaperone system represents a critical cellular machinery for protein folding, stability, and quality control. HSP90AA1, the inducible cytoplasmic isoform of HSP90, exhibits distinct conformational states that can be allosterically modulated to enhance specific client protein interactions. In the context of tau pathology, HSP90 demonstrates intrinsic disaggregation activity toward tau aggregates through a complex mechani...