RNA-Binding Competition Therapy for TDP-43 Cross-Seeding

**Background and Rationale** TAR DNA-binding protein 43 (TDP-43), encoded by the TARDBP gene, is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays critical roles in RNA processing, including transcription, splicing, transport, and stability regulation. Under pathological conditions, TDP-43 undergoes cytoplasmic mislocalization, hyperphosphorylation, ubiquitination, and aggregation, forming characteristic inclusions observed in amyotrophic lateral sclerosis (ALS), frontotemporal demen...