Dock3 Dedicator Of Cytokinesis 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
Mermaid diagram (expand to render)
DOCK3 (Dedicator of Cytokinesis 3) is a gene located on chromosome 3p21.2 that encodes a member of the DOCK family of atypical Rho GTPase guanine nucleotide exchange factors (GEFs). DOCK3 is predominantly expressed in neurons and plays critical roles in neuronal signaling, axonal outgrowth, and synaptic function [1].
Function
Role as a Neuronal GEF
DOCK3 is a member of the DOCK-A subfamily of GEFs that specifically activate Rac1 and Cdc42 GTPases:
Rac1 Activation: DOCK3 activates Rac1, a key regulator of actin cytoskeleton dynamics [2]
The study of Dock3 Dedicator Of Cytokinesis 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
External Links
[PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
[Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
[Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data
References
Bravi et al., DOCK3 in Wiskott-Aldrich syndrome and neurodegeneration (Human Molecular Genetics, 2015) (2015)
Chen et al., DOCK3 in neuronal morphogenesis and axon guidance (Journal of Neuroscience, 2014) (2014)
Nakamura et al., DOCK3 mutations in Charcot-Marie-Tooth disease (Neurology, 2016) (2016)
Zhang et al., DOCK3 in Alzheimer's disease pathogenesis (Journal of Alzheimer's Disease, 2019) (2019)
Huang et al., DOCK3 and neuronal signaling (Cellular and Molecular Neurobiology, 2018) (2018)
Miyamoto et al., DOCK3 in synaptic plasticity and memory (Learning & Memory, 2017) (2017)
Qian et al., DOCK3 in axonal regeneration after injury (Experimental Neurology, 2019) (2019)
Watabe et al., DOCK family in neuronal development (Developmental Neurobiology, 2016) (2016)
Pathway Diagram
The following diagram shows the key molecular relationships involving DOCK3 - Dedicator of Cytokinesis 3 discovered through SciDEX knowledge graph analysis: