DOCK3

Understanding Entity Pages

This page aggregates everything SciDEX knows about DOCK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

DOCK3 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Alzheimer, Inflammation. Connected to 19 entities in the SciDEX knowledge graph.

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graph TD
    DOCK3["DOCK3"]
    TLR4["TLR4"]
    NLRP3["NLRP3"]
    APP_PS1["APP/PS1"]
    SIRT3["SIRT3"]
    NF_KB["NF-kappaB"]
    ERBB4["ERBB4"]
    APP["APP"]
    MITOCHONDRIAL_DYSFUNCTION["Mitochondrial Dysfunction"]
    NEUROINFLAMMATION["Neuroinflammation"]
    INFLAMMATION["Inflammation"]
    ALZHEIMER["Alzheimer's Disease"]
    ALS["ALS"]
    NEURODEGENERATION["Neurodegeneration"]

    TLR4 -->|"activates"| DOCK3
    NLRP3 -->|"activates"| DOCK3
    APP_PS1 -->|"activates"| DOCK3
    
    DOCK3 -->|"activates"| SIRT3
    DOCK3 -->|"activates"| NF_KB
    DOCK3 -->|"activates"| ERBB4
    DOCK3 -->|"activates"| APP
    DOCK3 -->|"promotes"| MITOCHONDRIAL_DYSFUNCTION
    DOCK3 -->|"triggers"| NEUROINFLAMMATION
    DOCK3 -->|"promotes"| INFLAMMATION
    
    NEUROINFLAMMATION -->|"contributes to"| ALZHEIMER
    NEUROINFLAMMATION -->|"contributes to"| ALS
    INFLAMMATION -->|"drives"| NEURODEGENERATION
    MITOCHONDRIAL_DYSFUNCTION -->|"leads to"| NEURODEGENERATION

    style DOCK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style SIRT3 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style NF_KB fill:#4a1a6b,stroke:#333,stroke-width:2px
    style ERBB4 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style APP fill:#4a1a6b,stroke:#333,stroke-width:2px
    style TLR4 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style NLRP3 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style APP_PS1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style NEUROINFLAMMATION fill:#ef5350,stroke:#333,stroke-width:2px
    style INFLAMMATION fill:#ef5350,stroke:#333,stroke-width:2px
    style MITOCHONDRIAL_DYSFUNCTION fill:#ef5350,stroke:#333,stroke-width:2px
    style ALZHEIMER fill:#7d4200,stroke:#333,stroke-width:2px
    style ALS fill:#7d4200,stroke:#333,stroke-width:2px
    style NEURODEGENERATION fill:#7d4200,stroke:#333,stroke-width:2px