Gsk3A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Gsk3A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GSK3A ([Glycogen Synthase Kinase](/entities/gsk3-beta) 3 Alpha) is a serine/threonine-protein kinase that plays critical roles in neuronal function, synaptic plasticity, and neurodegeneration. It is a key therapeutic target for Alzheimer's disease and other neurodegenerative disorders. [@hooper2010]
Overview
Mermaid diagram (expand to render)
GSK3A (Glycogen Synthase Kinase 3 Alpha) is a serine/threonine-protein kinase that plays critical roles in neuronal function, synaptic plasticity, and neurodegeneration. It is a key therapeutic target for Alzheimer's disease and other neurodegenerative disorders. Unlike its close relative GSK3B, GSK3A contains a unique N-terminal flexible domain and has distinct neuronal functions, including regulation of tau phosphorylation, synaptic plasticity, and apoptosis. [@li2008]
Gene Information
Function
GSK3A encodes a serine/threonine-protein kinase that is constitutively active in [neurons](/entities/neurons). Unlike its close relative GSK3B (GSK3β), GSK3A contains a unique N-terminal flexible domain and has distinct neuronal functions.
Key Molecular Functions
[Tau](/proteins/tau) Phosphorylation: GSK3A phosphorylates [tau protein](/proteins/tau) at multiple sites (Ser199, Ser202, Thr205, Thr212, Ser396, Ser404), contributing to neurofibrillary tangle formation in Alzheimer's disease
The study of Gsk3A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
[Mandelkow EM, et al, (2001) (2001)](https://pubmed.ncbi.nlm.nih.gov/11146001/)
[Hooper C, et al, (2010) (2010)](https://pubmed.ncbi.nlm.nih.gov/20801953/)
[Li X, et al, (2008) (2008)](https://pubmed.ncbi.nlm.nih.gov/18691221/)
[Peineau S, et al, (2004) (2004)](https://pubmed.ncbi.nlm.nih.gov/15260958/)
[Wang Y, et al, (2012) (2012)](https://pubmed.ncbi.nlm.nih.gov/22875936/)
[Zhou X, et al, (2015) (2015)](https://pubmed.ncbi.nlm.nih.gov/25683225/)
[Liu X, et al, (2013) (2013)](https://pubmed.ncbi.nlm.nih.gov/23590537/)
[Hamel P, et al, (2017) (2017)](https://pubmed.ncbi.nlm.nih.gov/29139379/)
Pathway Diagram
The following diagram shows the key molecular relationships involving GSK3A Gene discovered through SciDEX knowledge graph analysis: