gene 695 words KG: GSK3A 2026-03-24
kind:genesection:genesstate:published
Contents

GSK3A Gene

🧬 Gene Info
Gene SymbolGSK3A
Full NameGlycogen Synthase Kinase 3 Alpha
Chromosome19q13.2
Protein TypeKinase
FunctionGSK3A encodes a serine/threonine-protein kinase that is constitutively active in neurons.
Molecular Weight52.9 kDa
PathwaysNF-κB, Wnt, PI3K, MAPK
UniProt IDP49840
NCBI Gene ID2931
Ensembl IDENSG00000105723
OMIM604489
GeneCardsGSK3A
Human Protein AtlasGSK3A
Drug/CompoundStage
TideglusibPhase II
Associated Diseasesneurodegeneration
InteractionsAPP, SIRT3, APP/PS1, MITOCHONDRIAL DYSFUNCTION, APOPTOSIS, OXIDATIVE STRESS
KG Connections27 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Wnt Signaling in Neurodegeneration
mechanism · KG edge: regulates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
SIRT3 - Sirtuin 3
gene · KG edge: activates

Knowledge Graph (12 edges)

GSK3A activates APP
GSK3A activates SIRT3
GSK3A expressed_in Neural Stem Cell
GSK3A associated_with GSK3B
GSK3A activates APP/PS1
GSK3A activates MITOCHONDRIAL DYSFUNCTION
GSK3A activates APOPTOSIS
GSK3A activates OXIDATIVE STRESS
GSK3A activates Alzheimer
GSK3A activates Apoptosis