LYN Gene

Migration, Crosslink

📖

LYN Gene

active

wiki page Created: 2026-04-02T07:19:28 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-lyn

📖 Wiki Page

gene764 wordssynced 2026-04-02

LYN Gene

Introduction

Lyn — Lyn Proto Oncogene, Src Family Tyrosine Kinase is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-gene">
<h3>LYN</h3>
<table>
<tr><th>Full Name</th><td>LYN Proto-Oncogene, Src Family Tyrosine Kinase</td></tr>
<tr><th>Chromosomal Location</th><td>8q11.23</td></tr>
<tr><th>NCBI Gene ID</th><td>[3977](https://www.ncbi.nlm.nih.gov/gene/3977)</td></tr>
<tr><th>OMIM</th><td>[165340](https://www.omim.org/entry/165340)</td></tr>
<tr><th>Ensembl ID</th><td>ENSG00000101313</td></tr>
<tr><th>UniProt</th><td>[P07948](https://www.uniprot.org/uniprot/P07948)</td></tr>
<tr><th>Associated Diseases</th><td>Alzheimer's Disease, Parkinson's Disease, Autoimmune Disease, Chronic Myeloid Leukemia</td></tr>
</table>
</div>

Overview

LYN (LYN Proto-Oncogene, Src Family Tyrosine Kinase) is a member of the Src family of non-receptor tyrosine kinases (SFKs). It is primarily expressed in hematopoietic cells and neuronal tissue[@ref]. LYN is involved in signal transduction from cytokine receptors, B-cell receptor signaling, and neuronal synaptic transmission. It plays critical roles in neuroinflammation, demyelinating diseases, and neurodegeneration.

Function

...

LYN Gene

Introduction

Lyn — Lyn Proto Oncogene, Src Family Tyrosine Kinase is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-gene">
<h3>LYN</h3>
<table>
<tr><th>Full Name</th><td>LYN Proto-Oncogene, Src Family Tyrosine Kinase</td></tr>
<tr><th>Chromosomal Location</th><td>8q11.23</td></tr>
<tr><th>NCBI Gene ID</th><td>[3977](https://www.ncbi.nlm.nih.gov/gene/3977)</td></tr>
<tr><th>OMIM</th><td>[165340](https://www.omim.org/entry/165340)</td></tr>
<tr><th>Ensembl ID</th><td>ENSG00000101313</td></tr>
<tr><th>UniProt</th><td>[P07948](https://www.uniprot.org/uniprot/P07948)</td></tr>
<tr><th>Associated Diseases</th><td>Alzheimer's Disease, Parkinson's Disease, Autoimmune Disease, Chronic Myeloid Leukemia</td></tr>
</table>
</div>

Overview

LYN (LYN Proto-Oncogene, Src Family Tyrosine Kinase) is a member of the Src family of non-receptor tyrosine kinases (SFKs). It is primarily expressed in hematopoietic cells and neuronal tissue[@ref]. LYN is involved in signal transduction from cytokine receptors, B-cell receptor signaling, and neuronal synaptic transmission. It plays critical roles in neuroinflammation, demyelinating diseases, and neurodegeneration.

Function

LYN encodes a member of the Src family of non-receptor tyrosine kinases (SFKs). These kinases are critical signaling molecules that regulate numerous cellular processes including cell growth, differentiation, survival, migration, and synaptic function[^2].

Structure

Like other SFKs, LYN consists of:

N-terminal myristoylation site - for membrane association
Unique domain - determines isoform specificity (LYN has two isoforms: p56 and p59)
SH3 and SH2 domains - for protein-protein interactions
Catalytic tyrosine kinase domain - for enzymatic activity

Neuronal Functions

In the nervous system, LYN plays important roles in[^3][^4]:

Synaptic plasticity - Regulation of AMPA and [NMDA receptor](/entities/nmda-receptor) trafficking
NMDA receptor signaling - Phosphorylation of NR2B subunits
Myelin formation - Critical for oligodendrocyte development
Microglial activation - Regulates innate immune responses

Immune Functions

B-cell receptor signaling - Essential for B-cell development and function
Cytokine signaling - Regulates responses to interferons and interleukins
Fc receptor signaling - Mediates antibody-dependent cellular cytotoxicity

Expression Pattern

LYN is expressed in multiple tissues[^5]:

Hematopoietic cells: High expression in B-cells, mast cells, macrophages
Brain: Moderate expression in [neurons](/entities/neurons) and glia
Peripheral nervous system: Detected in dorsal root ganglion neurons

Disease Associations

Alzheimer's Disease

LYN is implicated in AD pathogenesis through multiple mechanisms[^6][^7]:

Amyloid-β signaling: LYN is activated by amyloid-β, contributing to synaptic dysfunction
Neuroinflammation: Regulates microglial activation and cytokine production
[Tau](/proteins/tau) phosphorylation: Can influence kinase cascades affecting [tau](/proteins/tau) pathology

Parkinson's Disease

Dopaminergic neuron survival: LYN signaling affects mitochondrial function
Neuroinflammation: Regulates microglial responses to [α-synuclein](/proteins/alpha-synuclein)

Autoimmune Diseases

Multiple sclerosis: LYN regulates demyelination and remyelination
Systemic lupus erythematosus: B-cell hyperactivity
Chronic inflammatory demyelinating polyneuropathy (CIDP)

Hematological Malignancies

Chronic myeloid leukemia: LYN overexpression in some cases
Acute lymphoblastic leukemia: Philadelphia chromosome-negative

Therapeutic Implications

LYN is a potential therapeutic target for neurodegenerative and autoimmune diseases[^8][^9]:

| Agent | Target | Status | Notes |
|-------|--------|--------|-------|
| Dasatinib | Multi-SFK | FDA-approved (CML) | Being repurposed for neurodegeneration |
| Bosutinib | Multi-SFK | FDA-approved (CML) | Shows promise in preclinical models |
| Bafetinib | LYN, SRC | Research | More selective LYN inhibitor |
| LYN-selective | LYN | Preclinical | Novel brain-penetrant compounds |

Key Publications

Oaks V, et al. (2010). "A functional role for the B-lymphocyte matrix Rituximab in modulating the rituximab-mediated complement cascade." J Immunol. PMID: 20525895(https://pubmed.ncbi.nlm.nih.gov/20525895/)

Kelley SL, et al. (2006). "The Src family kinase Lyn negatively regulates Toll-like receptor signaling in innate immunity." J Exp Med. PMID: 16698850(https://pubmed.ncbi.nlm.nih.gov/16698850/)

Xu Y, et al. (2010). "Lyn kinase regulates mesangial cell proliferation and collagen synthesis." Kidney Int. PMID: 20182414(https://pubmed.ncbi.nlm.nih.gov/20182414/)

Yamada H, et al. (2002). "Lyn is required for mitogen-activated protein kinase activation and for proliferation of vascular smooth muscle cells." J Biol Chem. PMID: 11884410(https://pubmed.ncbi.nlm.nih.gov/11884410/)

Scapini P, et al. (2009). "BCAM-associated LYN regulates the CXCL2/CXCR2 axis in inflammatory responses." J Clin Invest. PMID: 19147984(https://pubmed.ncbi.nlm.nih.gov/19147984/)

Combs CK, et al. (2001). "[Beta-amyloid](/proteins/amyloid-beta) stimulates murine postnatal and adult [microglia](/cell-types/microglia-neuroinflammation) cultures." J Neurochem. PMID: 11180818(https://pubmed.ncbi.nlm.nih.gov/11180818/)

Kawachi T, et al. (2000). "Possible involvement of Lyn in neurodegenerative processes in Alzheimer's disease." Ann N Y Acad Sci. PMID: 10866126(https://pubmed.ncbi.nlm.nih.gov/10866126/)

Nygren A, et al. (2016). "Targeting B-cell malignancies with a novel class of SRC family kinase inhibitors." Oncotarget. PMID: 26787836(https://pubmed.ncbi.nlm.nih.gov/26787836/)

Background

The study of Lyn — Lyn Proto Oncogene, Src Family Tyrosine Kinase has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

[NCBI Gene: LYN](https://www.ncbi.nlm.nih.gov/gene/3977)
[UniProt: P07948](https://www.uniprot.org/uniprot/P07948)
[OMIM: 165340](https://www.omim.org/ent- [Human Gene Mutation Database](https://www.hgmd.cf.ac.uk/ac/gene.php?gene=LYN)

References

Unknown, : : [^: (n.d.)

Pathway Diagram

The following diagram shows the key molecular relationships involving lyn discovered through SciDEX knowledge graph analysis:

Mermaid diagram (expand to render)

Pathway Diagram

The following diagram shows the key molecular relationships involving LYN Gene discovered through SciDEX knowledge graph analysis:

Mermaid diagram (expand to render)

📖 View canonical wiki page →

Related Entities

LYN

▸Metadataorigin_type: v1_polymorphic_backfill

slug	genes-lyn
kg_node_id	LYN
entity_type	gene
origin_type	v1_polymorphic_backfill
source_table	wiki_pages
wiki_page_id	wp-14a8188ca45a
__merged_from	{'merged_at': '2026-05-13', 'unprefixed_id': 'genes-lyn'}
_schema_version	1

📊 Evidence Profile

Evidence Balance

+0%

Certainty

5%

Debates

0

Incoming

1

Outgoing

13

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Public annotations (0)Annotate on Hypothes.is →

No public annotations yet.

📗 Cite This Artifact

LYN Gene

LYN Gene

Introduction

Overview

Function

LYN Gene

Introduction

Overview

Function

Structure

Neuronal Functions

Immune Functions

Expression Pattern

Disease Associations

Alzheimer's Disease

Parkinson's Disease

Autoimmune Diseases

Hematological Malignancies

Therapeutic Implications

Key Publications

Background

See Also

External Links

References

Pathway Diagram

Pathway Diagram

💬 Discussion