Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LYN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | LYN |
| Chromosome | 8q13.1. |
| Protein Type | Receptor |
| Function | LYN encodes a member of the Src family of non-receptor tyrosine kinases (SFKs). |
| Primary Expression | hematopoietic cells and neuronal tissue[@ref] |
| Molecular Weight | 56 kDa |
| Amino Acids | 21 aa |
| Pathways | MAPK signaling, Oxidative Stress |
| Ensembl ID | ENSG00000101313 |
| GeneCards | LYN |
| Human Protein Atlas | LYN |
| N-terminal myristoylation site | for membrane association |
| Unique domain | determines isoform specificity (LYN has two isoforms: p56 and p59) |
| SH3 and SH2 domains | for protein-protein interactions |
| Catalytic tyrosine kinase domain | for enzymatic activity |
| Associated Diseases | cancer |
| Interactions | SRC, ULK1, AMPK, CD36, FYN, ADRB2 |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LYN["<b>LYN</b>"]
Inflammation{"Inflammation"}
LYN -->|"inhibits"| Inflammation
Als{"Als"}
LYN -->|"inhibits"| Als
Hepatitis{"Hepatitis"}
LYN -->|"inhibits"| Hepatitis
Ms{"Ms"}
LYN -->|"therapeutic target"| Ms
Cancer{"Cancer"}
LYN -->|"regulates"| Cancer
AMPK["AMPK"]
LYN -->|"inhibits"| AMPK
SRC["SRC"]
LYN -->|"activates"| SRC
neurodegeneration["neurodegeneration"]
LYN -->|"implicated in"| neurodegeneration
CD36["CD36"]
CD36 -->|"inhibits"| LYN
FYN["FYN"]
FYN -->|"inhibits"| LYN
FYN -->|"interacts with"| LYN
SRC -->|"interacts with"| LYN
ADRB2["ADRB2"]
ADRB2 -->|"interacts with"| LYN
GSK3B["GSK3B"]
GSK3B -->|"interacts with"| LYN
CANCER["CANCER"]
CANCER -->|"regulates"| LYN
style LYN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| duodenal cancer | amplified_in | disease | 0.90 |
| Inflammation | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Hepatitis | inhibits | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| SRC | activates | gene | 0.60 |
| cancer | associated_with | disease | 0.60 |
| ULK1 | activates | gene | 0.60 |
| AMPK | inhibits | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| MAPK | associated_with | gene | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| pyroptosis | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CD36 | inhibits | gene | 0.60 |
| FYN | inhibits | gene | 0.60 |
| FYN | interacts_with | gene | 0.60 |
| SRC | interacts_with | gene | 0.60 |
| ADRB2 | interacts_with | gene | 0.60 |
| GSK3B | interacts_with | gene | 0.60 |
| JNK | inhibits | gene | 0.60 |
| ERK1 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| DST | associated_with | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| AMPK | inhibits | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||