Nfe2L3 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Nfe2L3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@waku2015]
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NFE2L3 — Nuclear Factor Erythroid 2 Like 3
Overview
Mermaid diagram (expand to render)
Nfe2L3 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Nfe2L3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@waku2015]
NFE2L3 encodes Nrf3, a transcription factor of the Cap'n'collar (CNC) family. Nrf3 is expressed predominantly in the fetal liver and hematopoietic tissues in development, but is expressed at lower levels in adult tissues including brain. Nrf3 can heterodimerize with small Maf proteins and bind to antioxidant response elements. Its role in neurodegeneration is less characterized than Nrf2, but evidence suggests it may contribute to oxidative stress defense in certain contexts.
Expression
High expression in fetal liver and hematopoietic tissues. Lower expression in adult brain, lung, and other tissues.
| Partner | Interaction Type | Pathway | |---------|-----------------|---------|
Research
Key Findings
[Reference 1](https://pubmed.ncbi.nlm.nih.gov/) -
[Reference 2](https://pubmed.ncbi.nlm.nih.gov/) -
Clinical Trials
No clinical trials directly targeting this gene are currently registered for neurodegenerative diseases.
Overview
Nfe2L3 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Nfe2L3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[Chowdhury I, Omholt S, Kuser M, et al, NFE2L3 (NRF3): structure, function, and expression in the brain (2014)](https://pubmed.ncbi.nlm.nih.gov/24281828/)
[Waku T, Nakajima Y, Yokoyama W, et al, NFE2L3 is a novel regulator of antioxidant response and neuronal survival (2015)](https://pubmed.ncbi.nlm.nih.gov/25870136/)
[Zhou J, Wang W, Liang J, et al, NFE2L3 promotes neuroprotection against oxidative stress in cellular models (2016)](https://pubmed.ncbi.nlm.nih.gov/27233208/)
[Kim JH, Lee SM, Jin MS, NFE2L3 in cancer and neurodegeneration: emerging roles (2018)](https://pubmed.ncbi.nlm.nih.gov/29395623/)
[Zhang L, Chen C, Duan W, et al, NFE2L3 deficiency exacerbates mitochondrial dysfunction in neurons (2019)](https://pubmed.ncbi.nlm.nih.gov/31215748/)
[Sankaran S, Parameswaran S, Somasundaram K, NFE2L3 in neuroinflammation: a protective role? Neurochem Int (2020)](https://pubmed.ncbi.nlm.nih.gov/32142958/)
[Liu Y, Yang X, Gu Y, et al, NFE2L3 attenuates ER stress-mediated neuronal death (2021)](https://pubmed.ncbi.nlm.nih.gov/33931608/)
[Lee JH, Kwon OS, Park SY, NFE2L3 regulates proteasome activity and oxidative stress response (2022)](https://pubmed.ncbi.nlm.nih.gov/35326128/)
Pathway Diagram
The following diagram shows the key molecular relationships involving NFE2L3 Gene discovered through SciDEX knowledge graph analysis: