protein

NFE2L3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFE2L3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
7Outgoing
7Incoming

Summary

Page for NFE2L3 protein

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🔬 Protein Info
Gene SymbolNFE2L3
Full NameNuclear Factor Erythroid 2 Like 3
Chromosome7p15.2
Protein TypeTranscription Factor
FunctionThese complexes bind to Antioxidant Response Elements (ARE sequences, 5'-TGACnnnGC-3') in the promoter regions of target genes[@sykiotis2010].
Primary Expressionvarious brain regions, including:
Molecular Weight90 kDa
UniProt ID[Q9Y5U8](https://www.uniprot.org/uniprot/Q9Y5U8)
Ensembl IDENSG00000150347
OMIM607917
GeneCardsNFE2L3
Human Protein AtlasNFE2L3
Associated DiseasesOvarian Cancer
KG Connections14 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

NFE2L3 Gene

gene · 525 words

NFE2L3 Protein

protein · 1165 words

MAP1A Gene

gene · 1077 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    N0["NFE2L3"]
    N1["ADRA2A"]
    N1 -->|"associated with"| N0
    N2["CD36"]
    N2 -->|"associated with"| N0
    N3["MAP1A"]
    N3 -->|"associated with"| N0
    N4["CDC42EP3"]
    N4 -->|"associated with"| N0
    N5["FGFRL1"]
    N5 -->|"associated with"| N0
    N6["GRAMD1B"]
    N6 -->|"associated with"| N0
    N7["MYL9"]
    N7 -->|"associated with"| N0
    N8["Ovarian Cancer"]
    N0 -->|"therapeutic target"| N8
    N9["cancer"]
    N0 -->|"inhibits"| N9
    N10["SIGLEC11"]
    N0 -->|"associated with"| N10
    N11["SLC24A4"]
    N0 -->|"associated with"| N11
    N12["SPINT1"]
    N0 -->|"associated with"| N12
    N13["XPR1"]
    N0 -->|"associated with"| N13
    N14["neurodegeneration"]
    N0 -->|"implicated in"| N14

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 protein
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 disease
    class N9 disease
    class N10 gene
    class N11 gene
    class N12 gene
    class N13 gene

Outgoing (7)

TargetRelationTypeStr
Ovarian Cancertherapeutic_targetdisease0.85
Ovarian Cancerassociated_withdisease0.85
cancerinhibitsdisease0.60
SIGLEC11associated_withgene0.60
SLC24A4associated_withgene0.60

Incoming (7)

SourceRelationTypeStr
ADRA2Aassociated_withgene0.60
CD36associated_withgene0.60
MAP1Aassociated_withgene0.60
CDC42EP3associated_withgene0.60
FGFRL1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found