Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NFE2L3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NFE2L3 |
| Full Name | Nuclear Factor Erythroid 2 Like 3 |
| Chromosome | 7p15.2 |
| Protein Type | Transcription Factor |
| Function | These complexes bind to Antioxidant Response Elements (ARE sequences, 5'-TGACnnnGC-3') in the promoter regions of target genes[@sykiotis2010]. |
| Primary Expression | various brain regions, including: |
| Molecular Weight | 90 kDa |
| UniProt ID | [Q9Y5U8](https://www.uniprot.org/uniprot/Q9Y5U8) |
| Ensembl ID | ENSG00000150347 |
| OMIM | 607917 |
| GeneCards | NFE2L3 |
| Human Protein Atlas | NFE2L3 |
| Associated Diseases | Ovarian Cancer |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["NFE2L3"]
N1["ADRA2A"]
N1 -->|"associated with"| N0
N2["CD36"]
N2 -->|"associated with"| N0
N3["MAP1A"]
N3 -->|"associated with"| N0
N4["CDC42EP3"]
N4 -->|"associated with"| N0
N5["FGFRL1"]
N5 -->|"associated with"| N0
N6["GRAMD1B"]
N6 -->|"associated with"| N0
N7["MYL9"]
N7 -->|"associated with"| N0
N8["Ovarian Cancer"]
N0 -->|"therapeutic target"| N8
N9["cancer"]
N0 -->|"inhibits"| N9
N10["SIGLEC11"]
N0 -->|"associated with"| N10
N11["SLC24A4"]
N0 -->|"associated with"| N11
N12["SPINT1"]
N0 -->|"associated with"| N12
N13["XPR1"]
N0 -->|"associated with"| N13
N14["neurodegeneration"]
N0 -->|"implicated in"| N14
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class N0 protein
class N1 gene
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 disease
class N9 disease
class N10 gene
class N11 gene
class N12 gene
class N13 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Ovarian Cancer | therapeutic_target | disease | 0.85 |
| Ovarian Cancer | associated_with | disease | 0.85 |
| cancer | inhibits | disease | 0.60 |
| SIGLEC11 | associated_with | gene | 0.60 |
| SLC24A4 | associated_with | gene | 0.60 |
| SPINT1 | associated_with | gene | 0.60 |
| XPR1 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||