RAB38 Gene

RAB38 — RAB38, Member RAS Oncogene Family

Overview

Rab38 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Rab38 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@wasmeier2004]

<div class="infobox infobox-gene"> [@gamberi2013]
<table> [@bultema2014]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">RAB38, Member RAS Oncogene Family</th></tr> [@wang2015]
<tr><td><strong>Gene Symbol</strong></td><td>RAB38</td></tr> [@liu2019]
<tr><td><strong>Full Name</strong></td><td>RAB38, Member RAS Oncogene Family</td></tr> [@zhou2020]
<tr><td><strong>Chromosome</strong></td><td>11q14.2</td></tr> [@kim2022]
<tr><td><strong>NCBI Gene ID</strong></td><td>[28284](https://www.ncbi.nlm.nih.gov/gene/28284)</td></tr>
<tr><td><strong>OMIM</strong></td><td>606436</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000123892</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[O14964](https://www.uniprot.org/uniprot/O14964)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Parkinson's Disease, Hermansky-Pudlak Syndrome, Cancer, Pigmentation Disorders</td></tr>
</table>
</div>

Function

RAB38 — RAB38, Member RAS Oncogene Family

Overview

Rab38 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Rab38 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@wasmeier2004]

<div class="infobox infobox-gene"> [@gamberi2013]
<table> [@bultema2014]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">RAB38, Member RAS Oncogene Family</th></tr> [@wang2015]
<tr><td><strong>Gene Symbol</strong></td><td>RAB38</td></tr> [@liu2019]
<tr><td><strong>Full Name</strong></td><td>RAB38, Member RAS Oncogene Family</td></tr> [@zhou2020]
<tr><td><strong>Chromosome</strong></td><td>11q14.2</td></tr> [@kim2022]
<tr><td><strong>NCBI Gene ID</strong></td><td>[28284](https://www.ncbi.nlm.nih.gov/gene/28284)</td></tr>
<tr><td><strong>OMIM</strong></td><td>606436</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000123892</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[O14964](https://www.uniprot.org/uniprot/O14964)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Parkinson's Disease, Hermansky-Pudlak Syndrome, Cancer, Pigmentation Disorders</td></tr>
</table>
</div>

Function

RAB38 encodes a small GTPase involved in intracellular vesicle trafficking, particularly melanosome and lysosome-related organelle function. RAB38 regulates trafficking to lysosome-related organelles and is important for melanosome biogenesis. RAB38 and its partner RAB32 regulate mitochondrial quality control and have been implicated in Parkinson's disease. RAB38 variants may affect dopaminergic neuron survival through altered [autophagy](/entities/autophagy) and lysosomal function.

Expression

Expressed in brain (especially basal ganglia), melanocytes, platelets, and lung. Higher expression in pigmented tissues.

Disease Associations

| Disease | Mechanism |
|---------|-----------|
| Parkinson's Disease | |
| Hermansky-Pudlak Syndrome | |
| Cancer | |
| Pigmentation Disorders | |

Interactions

| Partner | Interaction Type | Pathway |
|---------|-----------------|---------|

Research

Key Findings

• [Reference 1](https://pubmed.ncbi.nlm.nih.gov/) -
• [Reference 2](https://pubmed.ncbi.nlm.nih.gov/) -

Clinical Trials

No clinical trials directly targeting this gene are currently registered for neurodegenerative diseases.

Overview

Rab38 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of Rab38 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

See Also

• [Parkinson's Disease](/diseases/parkinsons-disease)
• [Alpha-Synuclein](/mechanisms/alpha-synuclein)
• [/mechanisms/mitochondrial-dysfunction-ad](/mechanisms/mitochondrial-dysfunction-ad)
• [ROS](/entities/ros)
• [/mechanisms/synaptic-dysfunction-ad](/mechanisms/synaptic-dysfunction)mechanisms/synaptic-dysfunction)

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

External Resources

• [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/)
• [UniProt](https://www.uniprot.org/uniprot/)
• [Ensembl](https://www.ensembl.org/)
• [GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=)

References