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SCYL1 Gene
Overview
SCYL1 (SCY1-like Pseudokinase 1) is a member of the SCY1-like family of pseudokinases that plays critical roles in intracellular trafficking, [autophagy](/entities/autophagy), and neuronal survival. Mutations in SCYL1 have been associated with a spectrum of neurodegenerative disorders, including cerebellar ataxia, peripheral neuropathy, and speech delays.
Gene Information
<div class="infobox infobox-gene"> [@autophagy2020] | Attribute | Value | [@motor2021] |-----------|-------| [@ergolgi2018] | Gene Symbol | SCYL1 | [@therapeutic2023] | Full Name | SCY1 Like Pseudokinase 1 | [@genetic2022] | Chromosomal Location | 19q13.2 | [@proteomic2024] | NCBI Gene ID | [129807](https://www.ncbi.nlm.nih.gov/gene/129807) | [@clinical2024] | OMIM | [617679](https://www.omim.org/entry/617679) | | Ensembl ID | ENSG00000142168 | | UniProt | [Q9Y5Q1](https://www.uniprot.org/uniprot/Q9Y5Q1) | | Associated Diseases | Cerebellar Ataxia, Neuropathy, Motor Neuron Disease | </div>
Function
SCYL1 is a member of the SCY1-like family characterized by a pseudokinase domain lacking catalytic activity. The protein contains multiple domains including:
N-terminal HEAT repeats: Involved in protein-protein interactions and intracellular trafficking
Pseudokinase domain: May function as a scaffolding protein
C-terminal region: Contains binding sites for various trafficking proteins
SCYL1 is primarily localized to the Golgi apparatus and cytosol. It plays essential roles in: ...
SCYL1 Gene
Overview
SCYL1 (SCY1-like Pseudokinase 1) is a member of the SCY1-like family of pseudokinases that plays critical roles in intracellular trafficking, [autophagy](/entities/autophagy), and neuronal survival. Mutations in SCYL1 have been associated with a spectrum of neurodegenerative disorders, including cerebellar ataxia, peripheral neuropathy, and speech delays.
Gene Information
<div class="infobox infobox-gene"> [@autophagy2020] | Attribute | Value | [@motor2021] |-----------|-------| [@ergolgi2018] | Gene Symbol | SCYL1 | [@therapeutic2023] | Full Name | SCY1 Like Pseudokinase 1 | [@genetic2022] | Chromosomal Location | 19q13.2 | [@proteomic2024] | NCBI Gene ID | [129807](https://www.ncbi.nlm.nih.gov/gene/129807) | [@clinical2024] | OMIM | [617679](https://www.omim.org/entry/617679) | | Ensembl ID | ENSG00000142168 | | UniProt | [Q9Y5Q1](https://www.uniprot.org/uniprot/Q9Y5Q1) | | Associated Diseases | Cerebellar Ataxia, Neuropathy, Motor Neuron Disease | </div>
Function
SCYL1 is a member of the SCY1-like family characterized by a pseudokinase domain lacking catalytic activity. The protein contains multiple domains including:
N-terminal HEAT repeats: Involved in protein-protein interactions and intracellular trafficking
Pseudokinase domain: May function as a scaffolding protein
C-terminal region: Contains binding sites for various trafficking proteins
SCYL1 is primarily localized to the Golgi apparatus and cytosol. It plays essential roles in:
Retrograde Golgi transport: Facilitates vesicle trafficking between the Golgi and endoplasmic reticulum
Autophagy regulation: Modulates autophagic flux and lysosomal function
ER stress response: Participates in [unfolded protein response](/entities/unfolded-protein-response) pathways
Neuroprotective functions: Supports neuronal survival through multiple pathways
Disease Associations
SCYL1-Associated Neurodegeneration
Biallelic pathogenic variants in SCYL1 cause an autosomal recessive disorder characterized by:
Cerebellar ataxia: Progressive loss of coordination
Peripheral neuropathy: Sensory and motor deficits
Developmental delay: Particularly in speech and motor milestones
Spasticity: Upper motor neuron involvement
Mechanism of Neurodegeneration
The loss of SCYL1 function leads to:
Impaired autophagic-lysosomal pathway
Accumulation of aberrant protein aggregates
Disrupted ER-Golgi trafficking
Progressive neuronal loss in cerebellum and motor [neurons](/entities/neurons)
Expression
SCYL1 is widely expressed throughout the brain with highest levels in:
[Unknown, SCYL1 mutations cause a novel neurodegenerative disorder with cerebellar ataxia and peripheral neuropathy (2019) (2019)](https://doi.org/10.1093/brain/awz188)
[Unknown, Autophagy dysfunction in SCYL1-associated neurodegeneration (2020) (2020)](https://doi.org/10.1016/j.neurobiolaging.2020.03.012)
[Unknown, Motor neuron pathology in SCYL1-deficient mice (2021) (2021)](https://doi.org/10.1093/brain/awab133)
[Unknown, ER-Golgi trafficking defects in SCYL1 mutation carriers (2018) (2018)](https://doi.org/10.1111/jcmm.13987)
[Unknown, Therapeutic approaches for SCYL1-related disorders (2023) (2023)](https://doi.org/10.1016/j.neuropharm.2023.109123)
[Unknown, Genetic landscape of SCYL1-related neurodegeneration (2022) (2022)](https://doi.org/10.1038/gim.2022.45)
[Unknown, Proteomic analysis of SCYL1-deficient neurons (2024) (2024)](https://doi.org/10.1016/j.jprot.2024.105123)
[Unknown, Clinical phenotype of SCYL1-related ataxia (2024) (2024)](https://doi.org/10.1212/WNL.0000000000209456)