SEPTIN10 Gene

title: SEPTIN10 Gene

SEPTIN10 Gene

Overview

SEPTIN10 (Septin 10) is a member of the septin family of GTP-binding proteins that are essential for cytokinesis, cell polarity, and cellular organization. Septins form hetero-oligomeric complexes that function as scaffolds and barriers in various cellular processes. In [neurons](/entities/neurons), septins play important roles in synaptic function, axonal transport, and have been implicated in neurodegenerative diseases[@mostowy2011].

Gene Information

<div class="infobox infobox-gene">

| Property | Value |
|----------|-------|
| Gene Symbol | SEPTIN10 |
| Gene Name | Septin 10 |
| Chromosomal Location | 2q36.3 |
| NCBI Gene ID | 10244 |
| UniProt ID | Q9NSE2 |
| Ensembl ID | ENSG00000165799 |
| Gene Type | Protein Coding |

</div>

Protein Structure

SEPTIN10 belongs to the septin family characterized by:

• GTP-binding domain: Conserved P-loop NTP-binding region
• Polybasic region: For membrane association
• NC terminal: Variable region
• Coiled-coil domains: For protein-protein interactions

Septins assemble into filaments and rings, forming higher-order structures essential for their cellular functions[@kinoshita2003].

Biological Functions

Cytokinesis

• Forms contractile ring during cell division
• Serves as diffusion barrier
• Recruits cell division proteins

Cell Polarity

• Establishes cortical domains
• Maintains cell shape
• Regulates membrane organization

...

title: SEPTIN10 Gene

SEPTIN10 Gene

Overview

SEPTIN10 (Septin 10) is a member of the septin family of GTP-binding proteins that are essential for cytokinesis, cell polarity, and cellular organization. Septins form hetero-oligomeric complexes that function as scaffolds and barriers in various cellular processes. In [neurons](/entities/neurons), septins play important roles in synaptic function, axonal transport, and have been implicated in neurodegenerative diseases[@mostowy2011].

Gene Information

<div class="infobox infobox-gene">

| Property | Value |
|----------|-------|
| Gene Symbol | SEPTIN10 |
| Gene Name | Septin 10 |
| Chromosomal Location | 2q36.3 |
| NCBI Gene ID | 10244 |
| UniProt ID | Q9NSE2 |
| Ensembl ID | ENSG00000165799 |
| Gene Type | Protein Coding |

</div>

Protein Structure

SEPTIN10 belongs to the septin family characterized by:

• GTP-binding domain: Conserved P-loop NTP-binding region
• Polybasic region: For membrane association
• NC terminal: Variable region
• Coiled-coil domains: For protein-protein interactions

Septins assemble into filaments and rings, forming higher-order structures essential for their cellular functions[@kinoshita2003].

Biological Functions

Cytokinesis

• Forms contractile ring during cell division
• Serves as diffusion barrier
• Recruits cell division proteins

Cell Polarity

• Establishes cortical domains
• Maintains cell shape
• Regulates membrane organization

Neuronal Functions

• Synaptic vesicle organization
• Axonal transport regulation
• Dendrite morphogenesis
• Neurotransmitter release

Expression Pattern

SEPTIN10 is expressed in:

• Brain (neurons and glia)
• Testis
• Various epithelial tissues
• Proliferating cells

In neurons, septins are enriched in:

• Synaptic terminals
• Axon initial segments
• [Dendritic spines](/mechanisms/dendritic-spines)

Role in Neurodegeneration

Alzheimer's Disease

SEPTIN10 dysregulation is implicated in AD:

Amyloid-β interaction: Septins may interact with [Aβ](/proteins/amyloid-beta)

[Tau](/proteins/tau) pathology: Septin involvement in tau aggregation

Synaptic dysfunction: Altered septin dynamics affect synapses

Cytoskeletal changes: Disruption of neuronal cytoskeleton[@tth2019]

Parkinson's Disease

In PD, septins contribute to:

• [α-Synuclein](/proteins/alpha-synuclein) aggregation
• Mitochondrial dysfunction
• [Autophagy](/entities/autophagy) impairment
• Dopaminergic neuron vulnerability

Amyotrophic Lateral Sclerosis (ALS)

Septin alterations in ALS include:

• Motor neuron protein aggregates
• Axonal transport defects
• Synaptic dysfunction

Disease Associations

| Disease | Evidence | Mechanism |
|---------|----------|-----------|
| Alzheimer's Disease | Moderate | Synaptic dysfunction |
| Parkinson's Disease | Moderate | α-Synuclein interaction |
| ALS | Moderate | Protein aggregation |
| Cancer | Confirmed | Cell division defects |

Interacting Proteins

| Protein | Interaction | Function |
|---------|------------|----------|
| SEPT2 | Complex formation | Filament assembly |
| SEPT6 | Complex formation | Filament assembly |
| SEPT7 | Complex formation | Filament assembly |
| Actin | Binding | Cytoskeleton |
| Microtubules | Binding | Transport |

Therapeutic Potential

Septins represent potential therapeutic targets:

Septin inhibitors: For cancer treatment

Modulators of septin assembly: For neurodegeneration

Gene therapy approaches: Restore proper septin function

See Also

• [Cytoskeleton](/mechanisms/cytoskeleton) — Cellular structure
• [Alzheimer's Disease](/diseases/alzheimers-disease) — AD overview
• [Parkinson's Disease](/diseases/parkinsons-disease) — PD overview
• [Synaptic Function](/mechanisms/synaptic-transmission) — Synapse biology

External Links

• [NCBI Gene - SEPTIN10](https://www.ncbi.nlm.nih.gov/gene/10244)
• [UniProt - Q9NSE2](https://www.uniprot.org/uniprot/Q9NSE2)
• [GeneCards - SEPTIN10](https://www.genecards.org/cgi-bin/carddisp.pl?gene=SEPTIN10)

References

[Mostowy S et al, Septins: the fourth component of the cytoskeleton (2011)](https://pubmed.ncbi.nlm.nih.gov/21399614/)

[Kinoshita M, The septin family and its relationship to the nervous system (2003)](https://pubmed.ncbi.nlm.nih.gov/14675430/)

[Tòth K et al, Septins in neurodegenerative diseases (2019)](https://pubmed.ncbi.nlm.nih.gov/31487161/)