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Icahn School of Medicine at Mount Sinai

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slug	institutions-icahn-sinai
entity_type	institution
kg_node_id	None

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Linked Artifacts (60)

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪TREM2-Dependent Microglial Senescence Transition50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

related🔬What are the mechanisms underlying selective vulnerability o50%

related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying digital biomarkers and ai50%

related🔬What are the mechanisms underlying what are the mechanisms b50%

related🔬What are the mechanisms underlying synaptic pruning by micro50%

related🔬Investigate prion-like spreading of tau pathology through co50%

related🔬What are the mechanisms underlying selective vulnerability o50%

related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying digital biomarkers and ai50%

related🔬What are the mechanisms underlying what are the mechanisms b50%

related🔬What are the mechanisms underlying synaptic pruning by micro50%

related🔬Investigate prion-like spreading of tau pathology through co50%

related🧪APOE Isoform Conversion Therapy50%

related🧪APOE-TREM2 Interaction Modulation50%

related🧪TREM2-Mediated Selective Aggregate Clearance Pathway50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer45%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones45%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction45%

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides45%

mentions🧪Competitive APOE4 Domain Stabilization Peptides45%

mentions🧪Smartphone-Detected Motor Variability Correction45%

mentions🧪Enteric Nervous System Prion-Like Propagation Blockade45%

mentions🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation45%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination45%

mentions🧪TREM2-mediated microglial tau clearance enhancement45%

mentions📖Alpha-Synuclein - Biomarker40%

mentions📖Alzheimer's Disease40%

mentions📖Frontotemporal Dementia40%

mentions📖Lewy Body Dementia40%

mentions📖Neurodegeneration40%

mentions📖Parkinson's Disease40%

mentions📖LRRK2 — Leucine Rich Repeat Kinase 240%

mentions📖PICALM — Phosphatidylinositol Binding Clathrin Assembly Prot40%

mentions📖TREM2 — Triggering Receptor Expressed on Myeloid Cells 240%

mentions📖GSK-3β40%

mentions📖Parkin40%

mentions📖Ubiquitin40%

related🧪TREM2 Conformational Stabilizers for Synaptic Discrimination40%

related🧪Smartphone-Detected Motor Variability Correction40%

related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer40%

related🧪Enteric Nervous System Prion-Like Propagation Blockade40%

related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones40%

related🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation40%

related🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction40%

related🧪TREM2-mediated microglial tau clearance enhancement40%

related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides40%

related🧪Competitive APOE4 Domain Stabilization Peptides40%

related🧪LRP1-Dependent Tau Uptake Disruption40%

related🧪Extracellular Vesicle Biogenesis Modulation40%

related🧪TREM2-mediated microglial tau clearance enhancement40%

related🧪Perforant Path Presynaptic Terminal Protection Strategy40%

related🧪Reelin-Mediated Cytoskeletal Stabilization Protocol40%

related🧪Tau-Independent Microtubule Stabilization via MAP6 Enhanceme40%