ADGRV1 (Adhesion GPCR V1, also known as GPR98 or VLGR1) is one of the largest known G protein-coupled receptors, with a molecular weight of approximately 690 kDa. It belongs to the adhesion GPCR family and is encoded by the ADGRV1 gene (formerly GPR98). This protein plays important roles in cell-cell adhesion, sensory system development, and neuronal function. [@huitema2012]
ADGRV1 is primarily expressed in the central nervous system, particularly in the cerebellum, retina, and inner ear. Mutations in ADGRV1 are associated with Usher syndrome type IIA (USH2A), a recessive disorder characterized by hearing loss and retinitis pigmentosa. The protein is involved in phototransduction, auditory hair bundle organization, and neuronal migration. [@goodyear2010]
ADGRV1 (Adhesion GPCR V1, also known as GPR98 or VLGR1) is one of the largest known G protein-coupled receptors, with a molecular weight of approximately 690 kDa. It belongs to the adhesion GPCR family and is encoded by the ADGRV1 gene (formerly GPR98). This protein plays important roles in cell-cell adhesion, sensory system development, and neuronal function. [@huitema2012]
ADGRV1 is primarily expressed in the central nervous system, particularly in the cerebellum, retina, and inner ear. Mutations in ADGRV1 are associated with Usher syndrome type IIA (USH2A), a recessive disorder characterized by hearing loss and retinitis pigmentosa. The protein is involved in phototransduction, auditory hair bundle organization, and neuronal migration. [@goodyear2010]
== Structure == [@mcgee2006] ADGRV1 (GPR98/VLGR1) is one of the largest known GPCRs, with an extracellular N-terminus of over 5000 amino acids containing: [@nikkola2013]
Signal peptide at the N-terminus
Calx-beta domains (multiple) - likely involved in mechanosensing