Crebbp Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Crebbp Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
CREBBP Protein (CREB-binding protein, also known as CBP) is a transcriptional coactivator with intrinsic histone acetyltransferase (HAT) activity. This critical epigenetic regulator controls gene expression by modifying chromatin structure and interacting with numerous transcription factors, making it essential for learning, memory, and neuronal survival. [@vecsey2007]
Protein Information
Structure
CREBBP contains multiple functional domains:
N-terminal transcriptional adapter domain (TRD): Binds CREB and other transcription factors
HAT domain (KIX domain): Catalytic core acetylating histones
Bromodomain: Recognizes acetylated lysines
ZZ-type zinc finger: Additional protein interaction surface
Combination Therapy: Multiple approaches for transcriptional restoration
Key Publications
Chan HM, et al. (2001) The role of CREB-binding protein and p300 in nuclear receptor signalling. Nat Rev Mol Cell Biol 2(9):665-673. PMID: 11533700(https://pubmed.ncbi.nlm.nih.gov/11533700/)
The study of Crebbp Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
External Links
[PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
[Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
[Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data
References
[Chan HM, et al, The role of CREB-binding protein and p300 in nuclear receptor signalling.Nat Rev Mol Cell Biol 2001;2(9):665-673 (2001)](https://pubmed.ncbi.nlm.nih.gov/11533700/)