DRAM1 Protein

DRAM1 Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">DRAM1 Protein</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>DNA Damage Regulated Autophagy Modulator 1 (DRAM1)</td>
</tr>
<tr>
<td class="label">Gene</td>
<td>DRAM1</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>Q8WXX5</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>37 kDa</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Lysosomal membrane</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>DRAM family</td>
</tr>
<tr>
<td class="label">Compound</td>
<td>Mechanism</td>
</tr>
<tr>
<td class="label">Rapamycin</td>
<td>[mTOR](/mechanisms/mtor-signaling-pathway) inhibition</td>
</tr>
<tr>
<td class="label">Trehalose</td>
<td>mTOR-independent</td>
</tr>
<tr>
<td class="label">Metformin</td>
<td>AMPK activation</td>
</tr>
<tr>
<td class="label">Lithium</td>
<td>mTOR-independent</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/carcinoma" style="color:#ef9a9a">Carcinoma</a>, <a href="/wiki/lupus" style="color:#ef9a9a">Lupus</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">34 edges</a></td>
</tr>
</table>

DRAM1 Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">DRAM1 Protein</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>DNA Damage Regulated Autophagy Modulator 1 (DRAM1)</td>
</tr>
<tr>
<td class="label">Gene</td>
<td>DRAM1</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>Q8WXX5</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>37 kDa</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Lysosomal membrane</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>DRAM family</td>
</tr>
<tr>
<td class="label">Compound</td>
<td>Mechanism</td>
</tr>
<tr>
<td class="label">Rapamycin</td>
<td>[mTOR](/mechanisms/mtor-signaling-pathway) inhibition</td>
</tr>
<tr>
<td class="label">Trehalose</td>
<td>mTOR-independent</td>
</tr>
<tr>
<td class="label">Metformin</td>
<td>AMPK activation</td>
</tr>
<tr>
<td class="label">Lithium</td>
<td>mTOR-independent</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/carcinoma" style="color:#ef9a9a">Carcinoma</a>, <a href="/wiki/lupus" style="color:#ef9a9a">Lupus</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">34 edges</a></td>
</tr>
</table>

Dram1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

DRAM1 is a lysosomal membrane protein that serves as a key modulator of autophagy, the cellular process for degrading and recycling damaged proteins and organelles. It plays critical roles in neuronal survival under proteotoxic stress conditions. [@dram]

Overview

DRAM1 Protein (DNA Damage Regulated [Autophagy](/entities/autophagy) Modulator 1) is a transmembrane protein localized to the lysosome and endoplasmic reticulum. It functions as a key regulator of autophagy, particularly in response to cellular stress and DNA damage. DRAM1 protein is implicated in the pathogenesis of neurodegenerative diseases through its role in autophagic-lysosomal pathway dysfunction. [@drama]

Protein Information

Structure

Topology

• N-terminus: Cytoplasmic domain (aa 1-50)
• 6 Transmembrane Domains: α-helical
• Large Luminal Loop: Contains functional domains
• C-terminus: Cytoplasmic tail

Post-Translational Modifications

• N-linked Glycosylation: In luminal domain
• Phosphorylation: Regulates activity
• Ubiquitination: Affects protein stability

Normal Function

Autophagy Regulation

Lysosomal Biology

• Lysosomal Acidification: Maintains acidic pH
• Cathepsin Activation: Required for protease function
• Membrane Trafficking: Involved in endolysosomal pathway

Role in Disease

Alzheimer's Disease

• Autophagy Dysfunction: Reduced DRAM1 in AD brain
• [Aβ](/proteins/amyloid-beta) Clearance: Autophagy of amyloid aggregates
• Neuronal Death: Links autophagy to [apoptosis](/entities/apoptosis)
• Therapeutic Target: [mTOR](/entities/mtor) inhibitors enhance clearance

Parkinson's Disease

• α-syn Degradation: Autophagic clearance of [α-synuclein](/proteins/alpha-synuclein)
• Mitophagy: Mitochondrial quality control
• Dopaminergic Loss: SNc neuron vulnerability

ALS

• Protein Aggregation: Clearance of misfolded proteins
• Motor [Neuron](/entities/neurons) Survival: Protective function
• Dysregulation: Altered in ALS models

Therapeutic Targeting

Autophagy Modulators

Key Publications

11 function. DRAM - Nat Cell Biol (2006) - PMID: 16543938(https://pubmed.ncbi.nlm.nih.gov/16543938/)

See Also

• [DRAM1 Gene](/proteins/dram1-protein)
• [Autophagy-Lysosomal Pathway](/mechanisms/autophagy-lysosomal-pathway)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)

External Links

• [UniProt: DRAM1](https://www.uniprot.org/uniprotkb/Q8WXX5)
• [PhosphoSitePlus: DRAM1](https://www.phosphosite.org/proteinAction.action?id=9605283)

Background

The study of Dram1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References