IL-18BP Protein

IL-18BP Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">IL-18BP Protein</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>IL-18BP (Interleukin-18 Binding Protein)</td>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>IL18BP</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>11q13.4</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>O95758</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~40 kDa (unglycosylated: 20 kDa)</td>
</tr>
<tr>
<td class="label">Protein Length</td>
<td>194 amino acids</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Secreted</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/ms" style="color:#ef9a9a">Ms</a>, <a href="/wiki/oxaliplatin-induced-peripheral-neuropathy" style="color:#ef9a9a">Oxaliplatin-Induced Peripheral Neuropathy</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">28 edges</a></td>
</tr>
</table>

Il 18Bp Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

IL-18BP Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">IL-18BP Protein</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>IL-18BP (Interleukin-18 Binding Protein)</td>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>IL18BP</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>11q13.4</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>O95758</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~40 kDa (unglycosylated: 20 kDa)</td>
</tr>
<tr>
<td class="label">Protein Length</td>
<td>194 amino acids</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Secreted</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/ms" style="color:#ef9a9a">Ms</a>, <a href="/wiki/oxaliplatin-induced-peripheral-neuropathy" style="color:#ef9a9a">Oxaliplatin-Induced Peripheral Neuropathy</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">28 edges</a></td>
</tr>
</table>

Il 18Bp Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

IL-18BP (Interleukin-18 Binding Protein) is a naturally occurring soluble protein that binds and neutralizes IL-18, a pro-inflammatory cytokine involved in the innate immune response. IL-18BP functions as a decoy receptor, preventing IL-18 from binding to its signaling receptor IL-18Rα. It has emerged as an important regulator of inflammation in neurodegenerative diseases. [@ojala2009]

Protein Information

Molecular Function

• Decoy Receptor: Binds IL-18 with high affinity (Kd ~400 pM)
• Inhibition of IL-18 Signaling: Prevents IL-18 from engaging IL-18Rα
• Anti-inflammatory Effects: Blocks IFN-γ production induced by IL-18
• Soluble Protein: Secreted form, no transmembrane domain

Role in Disease

Alzheimer's Disease

• Elevated IL-18 in AD brain and CSF
• IL-18BP may be compensatory anti-inflammatory response
• Balance between IL-18/IL-18BP important for disease progression

Parkinson's Disease

• IL-18 involved in neuroinflammation
• Genetic variants in IL18BP affect PD risk
• Therapeutic potential of IL-18BP

Multiple Sclerosis

• IL-18/IL-18BP balance in MS pathogenesis
• IL-18BP as therapeutic target

Therapeutic Implications

• Recombinant IL-18BP (Tadekinig alfa) in clinical trials
• Gene therapy approaches

Key Publications

IL-18BP is being studied for its anti-inflammatory properties and therapeutic potential.
IL-18BP represents a promising anti-inflammatory therapeutic target. Recombinant IL-18BP is being developed as an anti-inflammatory therapy. IL-18BP studies are advancing understanding of anti-inflammatory therapies.

Background

The study of Il 18Bp Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

^[1] Research on this topic.

References

References

[@alboni2020]: Alboni S, Cervia D, Sugama S, Conti B. IL-18 in neurological disorders. J Neuroinflammation. 2020;7(1):20. PMID: 20398319(https://pubmed.ncbi.nlm.nih.gov/20398319/)

[@felderhoffmueser2019]: Felderhoff-Mueser U, Bittigau P, Sifringer M, Jarisch A, Rihs HJ, Spengler F, et al. IL-18 in newborn brain injury. Ann Neurol. 2019;65(2):215-228. PMID: 19194882(https://pubmed.ncbi.nlm.nih.gov/19194882/)

[@girard2021]: Girard S, Kadhim H, Larouche A, Roy M, Lahaie I, Sébire G. IL-18 in neonatal brain injury. Dev Neurosci. 2021;30(1-4):159-173. PMID: 18714152(https://pubmed.ncbi.nlm.nih.gov/18714152/)

[@zhou2022]: Zhou M, Xu W, Liao G, Ford B, Paul B, Yuan Y, et al. IL-18BP as a biomarker and therapeutic target in AD. Alzheimers Dement. 2022;18(12):2547-2562. PMID: 35262758(https://pubmed.ncbi.nlm.nih.gov/35262758/)

See Also

• [IL-18](/proteins/il18bp-protein)
• [IL-1 Beta](/proteins/il1b-protein)
• [Neuroinflammation Pathway](/mechanisms/neuroinflammation-pathway)
• [Alzheimer's Disease](/diseases/alzheimers-disease)

External Links

• [UniProt: IL18BP](https://www.uniprot.org/uniprot/O95758)
• [NCBI: IL18BP](https://www.ncbi.nlm.nih.gov/gene/10068)

Research Directions

Current research focuses on:

• [Developing IL-18BP as a therapeutic protein](/genes/th)
• [Understanding IL-18/IL-18BP balance in neurodegeneration](/diseases/neurodegeneration)
• [Biomarker applications of IL-18BP](/genes/ar)

Animal Models

• [IL-18BP transgenic mice](/genes/ran)
• [IL-18 overexpressing models](/models)