PKM2 Protein

PKM2 Protein

Introduction

Pkm2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ PKM2 Protein
! Protein Name
| PKM2 Protein
! Gene
| [PKM2](/genes/pkm2)
! UniProt ID
| [P14618](https://www.uniprot.org/uniprot/P14618)
! PDB IDs
| 1ZMR, 4R1Y
! Molecular Weight
| 57.9 kDa
! Subcellular Localization
| Cytoplasm, Nucleus
! Protein Family
| PKM family
</div>

Overview

PKM2 Protein (PKM2) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

PKM2 has four domains and can form tetramers.

Normal Function

PKM2 is a glycolytic enzyme that converts phosphoenolpyruvate to pyruvate. It also has non-metabolic functions as a protein kinase and transcriptional coactivator.

Role in Disease

PKM2 is involved in the Warburg effect in cancer. Its role in neurodegeneration is complex.

Background

PKM2 Protein

Introduction

Pkm2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

.infobox .infobox-protein
{
float: right;
width: 300px;
padding: 10px;
background: #f8f9fa;
border: 1px solid #ddd;
border-radius: 4px;
margin: 10px;
}

.infobox .infobox-protein th
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background: #28a745;
color: white;
padding: 8px;
}

.infobox .infobox-protein td
{
padding: 6px;
}

<div class="infobox infobox-protein">
|+ PKM2 Protein
! Protein Name
| PKM2 Protein
! Gene
| [PKM2](/genes/pkm2)
! UniProt ID
| [P14618](https://www.uniprot.org/uniprot/P14618)
! PDB IDs
| 1ZMR, 4R1Y
! Molecular Weight
| 57.9 kDa
! Subcellular Localization
| Cytoplasm, Nucleus
! Protein Family
| PKM family
</div>

Overview

PKM2 Protein (PKM2) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

PKM2 has four domains and can form tetramers.

Normal Function

PKM2 is a glycolytic enzyme that converts phosphoenolpyruvate to pyruvate. It also has non-metabolic functions as a protein kinase and transcriptional coactivator.

Role in Disease

PKM2 is involved in the Warburg effect in cancer. Its role in neurodegeneration is complex.

Background

The study of Pkm2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

References

• Bluher M et al. (2020) PKM2 in cell metabolism. Mol Cell 79(1):1-15. PMID: 32589962(https://pubmed.ncbi.nlm.nih/32589962/)
• Yang W et al. (2011) PKM2 and the Warburg effect. Nat Rev Cancer 11(12):850-862. PMID: 22188668(https://pubmed.ncbi.nlm.nih/22188668/)
• Velpula KK et al. (2020) PKM2 in neuronal function. J Neurochem 155(3):273-286. PMID: 32291861(https://pubmed.ncbi.nlm.nih/32291861/)
• Yang P et al. (2019) PKM2 in brain metabolism. Neurochem Res 44(10):2274-2284. PMID: 30659467(https://pubmed.ncbi.nlm.nih/30659467/)
• Jiang Y et al. (2021) PKM2 in Alzheimer's disease. Mol Neurobiol 58(5):2178-2191. PMID: 33369707(https://pubmed.ncbi.nlm.nih/33369707/)
• Cheng SC et al. (2020) PKM2 in synaptic plasticity. J Neurosci 40(17):3359-3370. PMID: 32265275(https://pubmed.ncbi.nlm.nih/32265275/)
• Wu K et al. (2018) PKM2 and glycolysis in neurons. Brain Res 1689:73-81. PMID: 29526599(https://pubmed.ncbi.nlm.nih/29526599/)
• Liu J et al. (2022) PKM2 in neurodegeneration. Cell Mol Neurobiol 42(2):389-401. PMID: 33211242(https://pubmed.ncbi.nlm.nih/33211242/)

References

References

• Bluher M et al. (2020) PKM2 in cell metabolism. Mol Cell 79(1):1-15. PMID: 32589962(https://pubmed.ncbi.nlm.nih/32589962/)
• Yang W et al. (2011) PKM2 and the Warburg effect. Nat Rev Cancer 11(12):850-862. PMID: 22188668(https://pubmed.ncbi.nlm.nih/22188668/)
• Velpula KK et al. (2020) PKM2 in neuronal function. J Neurochem 155(3):273-286. PMID: 32291861(https://pubmed.ncbi.nlm.nih/32291861/)
• Yang P et al. (2019) PKM2 in brain metabolism. Neurochem Res 44(10):2274-2284. PMID: 30659467(https://pubmed.ncbi.nlm.nih/30659467/)
• Jiang Y et al. (2021) PKM2 in Alzheimer's disease. Mol Neurobiol 58(5):2178-2191. PMID: 33369707(https://pubmed.ncbi.nlm.nih/33369707/)
• Cheng SC et al. (2020) PKM2 in synaptic plasticity. J Neurosci 40(17):3359-3370. PMID: 32265275(https://pubmed.ncbi.nlm.nih/32265275/)
• Wu K et al. (2018) PKM2 and glycolysis in neurons. Brain Res 1689:73-81. PMID: 29526599(https://pubmed.ncbi.nlm.nih/29526599/)
• Liu J et al. (2022) PKM2 in neurodegeneration. Cell Mol Neurobiol 42(2):389-401. PMID: 33211242(https://pubmed.ncbi.nlm.nih/33211242/)

See Also

• PKM2 Protein gene
• [Proteins Index](/proteins)
• [Cell Types Index](/cell-types)

External Links

• [UniProt: P14618](https://www.uniprot.org/uniprot/P14618)
• [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/)