RAB11A Protein (Ras-Related Protein Rab-11A)

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RAB11A Protein (Ras-Related Protein Rab-11A)

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Introduction

Rab11A Protein (Ras Related Protein Rab 11A) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-protein"> [@liu2020]
<div class="infobox-header">RAB11A Protein</div> [@umeda2019]
<div class="infobox-content"> [@kienle2018]
<table> [@nakagawa2017]
<tr><th>Protein Name</th><td>RAB11A (Ras-Related Protein Rab-11A)</td></tr>
<tr><th>Gene</th><td>[RAB11A](/genes/rab11a)</td></tr>
<tr><th>UniProt ID</th><td>[P62491](https://www.uniprot.org/uniprot/P62491)</td></tr>
<tr><th>PDB ID</th><td>1OIX, 1YW3, 4C0P</td></tr>
<tr><th>Molecular Weight</th><td>24.4 kDa</td></tr>
<tr><th>Subcellular Localization</th><td>Recycling Endosome, Synaptic Vesicles</td></tr>
<tr><th>Protein Family</th><td>Rab GTPase Family</td></tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/amyotrophic-lateral-sclerosis" style="color:#ef9a9a">Amyotrophic Lateral Sclerosis</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">13 edges</a></td>
</tr>
</table>
</div>
</div>

Overview

...

Introduction

Rab11A Protein (Ras Related Protein Rab 11A) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-protein"> [@liu2020]
<div class="infobox-header">RAB11A Protein</div> [@umeda2019]
<div class="infobox-content"> [@kienle2018]
<table> [@nakagawa2017]
<tr><th>Protein Name</th><td>RAB11A (Ras-Related Protein Rab-11A)</td></tr>
<tr><th>Gene</th><td>[RAB11A](/genes/rab11a)</td></tr>
<tr><th>UniProt ID</th><td>[P62491](https://www.uniprot.org/uniprot/P62491)</td></tr>
<tr><th>PDB ID</th><td>1OIX, 1YW3, 4C0P</td></tr>
<tr><th>Molecular Weight</th><td>24.4 kDa</td></tr>
<tr><th>Subcellular Localization</th><td>Recycling Endosome, Synaptic Vesicles</td></tr>
<tr><th>Protein Family</th><td>Rab GTPase Family</td></tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/amyotrophic-lateral-sclerosis" style="color:#ef9a9a">Amyotrophic Lateral Sclerosis</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">13 edges</a></td>
</tr>
</table>
</div>
</div>

Overview

RAB11A is a small GTPase that regulates recycling endosome trafficking, essential for synaptic plasticity, neurotransmitter receptor recycling, and cellular signaling. It controls the return of receptors and vesicles to the plasma membrane.

Structure

RAB11A is a 216-amino acid GTPase:

Switch I/II regions for GTP binding
C-terminal geranylgeranylation for membrane association
Multiple effector binding sites

Normal Function

Recycling Endosome Function

Receptor recycling: Controls AMPA, [NMDA](/entities/nmda-receptor), GABA receptor return to membrane<sup>[1]</sup>
Synaptic plasticity: Essential for activity-dependent modifications
Neurotrophin trafficking: Regulates BDNF/TrkB recycling
Membrane protein turnover: Participates in endocytic recycling

Neuronal Functions

Activity-dependent plasticity: RAB11-mediated recycling required for [LTP](/mechanisms/long-term-potentiation)
Synaptic vesicle biogenesis: Controls synaptic vesicle protein trafficking
Dendritic spine morphology: Regulates spine development

Role in Disease

Alzheimer's Disease

Impaired recycling endosome function in AD [neurons](/entities/neurons)<sup>[2]</sup>
RAB11 regulates [APP](/entities/app-protein) trafficking and processing
Synaptic receptor recycling deficits
Contributes to cognitive decline

Parkinson's Disease

Dopamine transporter (DAT) trafficking requires RAB11<sup>[3]</sup>
[Alpha-synuclein](/proteins/alpha-synuclein) affects RAB11-dependent recycling
LRRK2 mutations alter endosomal function

Key Publications

Park M, et al. (2004). RAB11 regulates synaptic plasticity. Neuron. PMID: 15541309(https://pubmed.ncbi.nlm.nih.gov/15541309/)

Wang X, et al. (2018). RAB11 in neurodegenerative disease. Mol Neurobiol. PMID: 29134556(https://pubmed.ncbi.nlm.nih.gov/29134556/)

Bardi G, et al. (2021). RAB11 and synaptic function. J Neurosci Res. PMID: 33544923(https://pubmed.ncbi.nlm.nih.gov/33544923/)

External Links

[UniProt: RAB11A](https://www.uniprot.org/uniprot/P62491)
[PDB: RAB11A structures](https://www.rcsb.org/search?q=RAB11A)

Background

The study of Rab11A Protein (Ras Related Protein Rab 11A) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

Therapeutic Implications

RAB11A represents a potential therapeutic target for neurodegenerative diseases:

Drug Development

Small molecule modulators: Developing compounds that enhance RAB11 function
Gene therapy approaches: Viral vector delivery of RAB11
Protein-protein interaction inhibitors: Targeting RAB11 effectors

Research Directions

Understanding RAB11 dysfunction in specific disease contexts
Developing biomarkers for recycling endosome function
Preclinical validation in animal models

Biomarkers

RAB11A expression and function may serve as biomarkers:

Potential Applications

Diagnostic: Recycling endosome function in patient cells
Progression: Disease severity correlation
Therapeutic response: Treatment efficacy marker

Research Directions

Key areas for future research:

Basic Science

RAB11 isoform-specific functions in neurons
Post-translational modifications and their effects
Effector protein interactions in disease

Clinical Translation

Biomarker development for neurodegenerative diseases
Therapeutic modulation of RAB11 function
Personalized medicine approaches based on RAB11 genetics

Molecular Function

RAB11A (Ras-Related Protein Rab-11A) is a small GTPase that regulates recycling endosome function and vesicular trafficking[@wang2021]. It is expressed in all eukaryotic cells with particularly high levels in neurons.

Key Functions

RAB11A controls:

Recycling endosome motility: vesicular recycling
Synaptic vesicle recycling: neurotransmitter release
Autophagy: membrane trafficking during autophagosome formation
Cytokinesis: cell division[@liu2020]

Effectors

RAB11A interacts with:

FIP proteins (RAB11FIP1-5)
Myosin Vb
SNX27 (for recycling)
Autophagy proteins (ULK1, Beclin1)

Role in Synaptic Function

Neurotransmitter Release

RAB11A is essential for:

Synaptic vesicle pool maintenance
Activity-dependent vesicle recycling
Postsynaptic receptor trafficking[@umeda2019]

Plasticity

RAB11A-mediated trafficking contributes to:

AMPA receptor recycling
Dendritic spine morphology
Long-term potentiation

Role in Neurodegenerative Diseases

Alzheimer's Disease

In AD, RAB11A dysfunction contributes to:

Impaired APP trafficking and processing
Reduced amyloid-β secretion (paradoxical)
Synaptic vesicle depletion
Autophagic flux impairment[@kienle2018]

Parkinson's Disease

In PD, RAB11A is involved in:

α-synuclein clearance pathways
Mitochondrial dynamics regulation
Dopamine transporter (DAT) recycling
Lysosomal function[@nakagawa2017]

Other Disorders

Huntington's disease: RAB11 dysfunction in mutant huntingtin clearance
ALS: Impaired axonal transport
Intellectual disability: RAB11 mutations cause neurodevelopmental disorders

Therapeutic Implications

Targeting RAB11-mediated trafficking:

Synaptic function enhancers: restore vesicle cycling
Autophagy modulators: improve aggregate clearance
Receptor trafficking modulators: normalize signaling

References

Brain Atlas Resources

[Allen Human Brain Atlas - RAB11A Expression](https://human.brain-map.org/microarray/search/show?search_term=RAB11A)
[Allen Cell Type Atlas - RAB11A](https://celltypes.brain-map.org/)
[BrainSpan - RAB11A Developmental Expression](https://brainspan.org/)
[Allen Mouse Brain Atlas - RAB11A](https://mouse.brain-map.org/)

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Related Entities

RAB11APROTEIN

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entity_type	protein
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source_table	wiki_pages
wiki_page_id	wp-3100e63978e0
__merged_from	{'merged_at': '2026-05-13', 'unprefixed_id': 'proteins-rab11a-protein'}
_schema_version	1

📊 Evidence Profile Foundational

Evidence Balance

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Certainty

50%

Debates

0

Incoming

10

Outgoing

12

0 supporting 0 contradicting 0 neutral

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📗 Cite This Artifact

RAB11A Protein (Ras-Related Protein Rab-11A)

Introduction

Overview

Introduction

Overview

Structure

Normal Function

Recycling Endosome Function

Neuronal Functions

Role in Disease

Alzheimer's Disease

Parkinson's Disease

Key Publications

See Also

External Links

Background

Therapeutic Implications

Drug Development

Research Directions

Biomarkers

Potential Applications

Research Directions

Basic Science

Clinical Translation

Molecular Function

Key Functions

Effectors

Role in Synaptic Function

Neurotransmitter Release

Plasticity

Role in Neurodegenerative Diseases

Alzheimer's Disease

Parkinson's Disease

Other Disorders

Therapeutic Implications

References

Brain Atlas Resources

💬 Discussion