P2RY12-MTOR pathway interaction in VSMCs

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P2RY12-MTOR pathway interaction in VSMCs

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experiment Created: 2026-04-04T05:26:15 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-764173ae-f63f-452f-b821-2

🧫 Experiment Protocol Cell Biologyproposed

Related Entities

P2RY12, MTOR

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-04T05:26:15.811936'}
p_value	None
protocol	MTOR inhibition with rapamycin, genetic MTOR knockdown, cholesterol efflux assays, autophagy marker analysis
effect_size	None
sample_size	None
source_pmid	32160082
extracted_at	2026-04-03T22:26:15.619136
_schema_version	1
experiment_type	cell_biology
success_criteria	Restoration of cholesterol efflux and autophagy when MTOR is blocked
expected_outcomes	MTOR inhibition would reverse P2RY12-mediated effects on cholesterol efflux and autophagy
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

125

Outgoing

0 supporting 0 contradicting 0 neutral

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🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

experiment-exp-764173ae-f63f-4→paper-32160082

This artifact has no version history yet.

Linked Artifacts (152)

experiment_target📖P2RY12100%

mentions📖P2RY12100%

mentions📖MTOR100%

derives_from📄The P2RY12 receptor promotes VSMC-derived foam cell formatio100%

mentions📖MTOR Protein80%

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mentions📖MTOR Gene70%

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related📖PI3K Protein63%

related📖akt-protein63%

related📖pi3k-akt-signaling63%

related📖MTOR (Redirect)63%

related📖PI3K p110α Protein63%

related📖MTOR Gene63%

related📖AKT (Protein Kinase B) Neurons63%

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Reference URLs

Canonical (singular)/artifact/experiment-exp-764173ae-f63f-452f-b821-29c03501fa7ccanonical

Canonical (plural, REST)/artifacts/experiment-exp-764173ae-f63f-452f-b821-29c03501fa7calias

Type prefix (singular)/experiment/experiment-exp-764173ae-f63f-452f-b821-29c03501fa7calias

Type prefix (plural)/experiments/experiment-exp-764173ae-f63f-452f-b821-29c03501fa7calias

API (JSON)/api/artifacts/experiment-exp-764173ae-f63f-452f-b821-29c03501fa7capi

Citation — BibTeX/artifacts/experiment-exp-764173ae-f63f-452f-b821-29c03501fa7c/cite?fmt=bibtexexport

Citation — RIS/artifacts/experiment-exp-764173ae-f63f-452f-b821-29c03501fa7c/cite?fmt=risexport

Citation — CSL-JSON/artifacts/experiment-exp-764173ae-f63f-452f-b821-29c03501fa7c/cite?fmt=cslexport

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[P2RY12-MTOR pathway interaction in VSMCs](http://scidex.ai/artifact/experiment-exp-764173ae-f63f-452f-b821-29c03501fa7c)

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http://scidex.ai/artifact/experiment-exp-764173ae-f63f-452f-b821-29c03501fa7c

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