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MTOR Gene

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-mtor
Related Entities
MTOR
Metadata
sluggenes-mtor
entity_typegene
kg_node_idMTOR
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (311)
related🧫mTOR inhibitor validation experiment100%
mentions🧫iPSC-NPC effects on astrocytes in vitro ICH model80%
mentions🧫iPSC-NPC transplantation in ICH animal model80%
mentions🧫AMPK knockdown validation experiment80%
related🧪APOE-Dependent Autophagy Restoration80%
related🧫iPSC-NPC effects on astrocytes in vitro ICH model72%
related🧫iPSC-NPC transplantation in ICH animal model72%
related🧫AMPK knockdown validation experiment72%
mentions🧪APOE-Dependent Autophagy Restoration70%
mentions🧫P2RY12-MTOR pathway interaction in VSMCs70%
mentions🧫In vivo autophagy modulation in atherosclerotic mice70%
mentions🧪APOE Isoform Conversion Therapy70%
mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%
mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy70%
mentions🧪Circadian-Synchronized Proteostasis Enhancement70%
related🔬What are the mechanisms underlying mechanistic role of apoe 70%
see_also🧪APOE-Dependent Autophagy Restoration70%
mentions🔬What are the mechanisms underlying mechanistic role of apoe 65%
mentions🔬Senescent cell clearance as neurodegeneration therapy65%
related🧫P2RY12-MTOR pathway interaction in VSMCs63%
related🧫In vivo autophagy modulation in atherosclerotic mice63%
related🧪APOE Isoform Conversion Therapy63%
related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%
related🧪APOE4-Selective Lipid Nanoemulsion Therapy63%
related🧪Circadian-Synchronized Proteostasis Enhancement63%
mentions🧪TREM2-Mediated Selective Aggregate Clearance Pathway60%
related🧪APOE-Dependent Autophagy Restoration60%
see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%
see_also📖ACTB Gene60%
see_also📖ACTN2 — Actinin Alpha 260%
see_also📖ACVR1 Gene60%
see_also📖ANT2 (Adenine Nucleotide Translocator 2)60%
see_also📖ERCC3 Gene60%
see_also📖igf2bp360%
see_also📖LEPR — Leptin Receptor60%
see_also📖NLGN3 Gene60%
see_also📖NLR Family Member X160%
see_also📖NPRL2 Gene60%
see_also📖NPRL3 Gene60%
see_also📖OGG1 Gene60%
see_also📖pck260%
see_also📖PHF8 (PHD Finger Protein 8)60%
see_also📖ppp1ca60%
see_also📖RNF260%
see_also📖STAU2 Gene60%
see_also📖TLR8 Gene60%
see_also📖VMAT2 Gene60%
see_also📖ACLY Inhibition Rescues Alpha-Synuclein Autophagy60%
see_also📖Metabolic Dysfunction and Insulin Signaling Impairment Pathw60%
see_also📖GLB1 Gene60%
see_also📖IL11 Gene60%
see_also📖SYN1 (Synapsin-1)60%
see_also📖vps2660%
see_also📖ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Member 460%
see_also📖Angiogenesis Pathway60%
see_also📖Glycolysis Metabolism in Neurodegeneration60%
see_also📖Excitotoxicity60%
see_also📖IRAK4 Kinase Modulation Therapy for Neurodegeneration60%
see_also📖spinal-cord60%
see_also📖Retinal Ganglion Cells in Alzheimer's Disease60%
see_also📖L1CAM (L1 Cell Adhesion Molecule)60%
see_also📖LIMK2 Gene60%
see_also📖ABCG1 Gene60%
see_also📖HEXB Gene - Hexosaminidase Beta60%
see_also📖PMP22 — Peripheral Myelin Protein 2260%
see_also📖STX11 Gene60%
see_also📖TIMM10 — Mitochondrial Import Inner Membrane Translocase Sub60%
see_also📖timm17a60%
see_also📖TIMM960%
see_also📖FKBP1A60%
see_also📖PTK2 Gene - Focal Adhesion Kinase60%
see_also📖SPG21 Gene60%
see_also📖CEBPD Gene60%
see_also📖ERP57 (PDIA3) — Protein Disulfide Isomerase Family A Member 60%
see_also📖KAT7 — Lysine Acetyltransferase 7 (HBO1/MYST2)60%
see_also📖OTUD3 — OTU Deubiquitinase 360%
see_also📖PDIA3 - Protein Disulfide Isomerase Family A Member 360%
see_also📖slc1a560%
see_also📖SUZ1260%
see_also📖XPA Gene60%
see_also📖SGLT2 Inhibitor Neuroprotection Therapy60%
see_also📖Growth Factor Signaling in 4R-Tauopathies60%
see_also📖Protein Synthesis Pathway60%
see_also📖Synaptogenesis in Neurodegeneration60%
see_also📖ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member 160%
see_also📖ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member 260%
see_also📖DHX9 — DEAH-Box Helicase 960%
see_also📖dvl260%
see_also📖KCNT1 Gene - Slack Channel60%
see_also📖LAMTOR1 - Late Endosomal/Lysosomal Adaptor 160%
see_also📖PHOX2B Gene60%
related🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro55%
related🧪TREM2-Mediated Selective Aggregate Clearance Pathway54%
mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%
mentions🧪Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration50%
mentions🧪HSP90-Tau Disaggregation Complex Enhancement50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
mentions🧪VCP-Mediated Autophagy Enhancement50%
mentions🧪SASP-Mediated Cholinergic Synapse Disruption50%
mentions🧪Age-Dependent Complement C4b Upregulation Drives Synaptic Vu50%
mentions🧪Metabolic Reprogramming via Microglial Glycolysis Inhibition50%
mentions🧪Astroglial Gap Junction Coordination via Connexin-43 Phospho50%
mentions🧪Metabolic Circuit Breaker via Lipid Droplet Modulation50%
mentions🧪AMPK hypersensitivity in astrocytes creates enhanced mitocho50%
mentions🧪Nutrient-Sensing Epigenetic Circuit Reactivation50%
mentions🧪SIRT6-NAD+ Axis Enhancement Therapy50%
mentions🧪Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics50%
mentions🧪SASP-Mediated Complement Cascade Amplification50%
mentions🧪Heat Shock Protein 70 Disaggregase Amplification50%
mentions🧪Autophagosome Maturation Checkpoint Control50%
mentions🧪Glymphatic System-Enhanced Antibody Clearance Reversal50%
mentions🧪Hypocretin-Neurogenesis Coupling Therapy50%
mentions🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation50%
mentions🧪Bacterial Enzyme-Mediated Dopamine Precursor Synthesis50%
mentions🧪Orexin-Microglia Modulation Therapy50%
mentions🧪Lysosomal Calcium Channel Modulation Therapy50%
mentions🧪Membrane Cholesterol Gradient Modulators50%
mentions🧪Metabolic Switch Targeting for A1→A2 Repolarization50%
mentions🧪Transcriptional Autophagy-Lysosome Coupling50%
mentions🧪Digital Twin-Guided Metabolic Reprogramming50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Circadian Clock-Autophagy Synchronization50%
mentions🧪Ephrin-B2/EphB4 Axis Manipulation50%
mentions🧪Microbial Inflammasome Priming Prevention50%
mentions🧪Phase-Separated Organelle Targeting50%
mentions🧪Nucleolar Stress Response Normalization50%
mentions🧪Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution50%
mentions🧪Purinergic P2Y12 Inverse Agonist Therapy50%
mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%
mentions🧪Circadian-Synchronized Proteostasis Enhancement50%
mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%
mentions🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
mentions🧪APOE Isoform Expression Across Glial Subtypes50%
mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%
mentions🧪Senescent Microglia Resolution via Maresins-Senolytics Combi50%
mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%
mentions🧪Circadian Rhythm Entrainment of Reactive Astrocytes50%
mentions🧪Chromatin Accessibility Restoration via BRD4 Modulation50%
mentions🧪Lysosomal Membrane Repair Enhancement50%
mentions🧪Temporal Decoupling via Circadian Clock Reset50%
mentions🧪FOXO3-Longevity Pathway Epigenetic Reprogramming50%
mentions🧪Stress Granule Phase Separation Modulators50%
mentions🧪RNA Granule Nucleation Site Modulation50%
mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%
mentions🧪Senescence-Induced Lipid Peroxidation Spreading50%
mentions🧪Astrocyte-Mediated Neuronal Epigenetic Rescue50%
mentions🧪Lysosomal Enzyme Trafficking Correction50%
mentions🧪KDM6A-Mediated H3K27me3 Rejuvenation50%
mentions🧪Lysosomal Positioning Dynamics Modulation50%
mentions🧪LRP1-Dependent Tau Uptake Disruption50%
mentions🧪Netrin-1 Gradient Restoration50%
mentions🧪Partial Neuronal Reprogramming via Modified Yamanaka Cocktai50%
mentions🧪Microglial Purinergic Reprogramming50%
mentions🧪PARP1 Inhibition Therapy50%
mentions🧪Extracellular Matrix Stiffness Modulation50%
mentions🧪Perforant Path Presynaptic Terminal Protection Strategy50%
mentions🧪Mitochondrial-Lysosomal Contact Site Engineering50%
mentions🧪Reelin-Mediated Cytoskeletal Stabilization Protocol50%
mentions🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK50%
mentions🧪Synaptic Vesicle Tau Capture Inhibition50%
mentions🧪Cryptic Exon Silencing Restoration50%
mentions🧪Glycine-Rich Domain Competitive Inhibition50%
mentions🧪Cross-Seeding Prevention Strategy50%
mentions🧪TFAM overexpression creates mitochondrial donor-recipient gr50%
mentions🧪Blood-Brain Barrier SPM Shuttle System50%
mentions🧪Quantum Coherence Disruption in Cellular Communication50%
mentions🧪Brain Insulin Resistance with Glucose Transporter Dysfunctio50%
mentions🧪APOE-TREM2 Interaction Modulation50%
mentions🧪TREM2-Dependent Microglial Senescence Transition50%
mentions🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction50%
mentions🧪TFEB-PGC1α Mitochondrial-Lysosomal Decoupling50%
mentions🧪CYP46A1 Overexpression Gene Therapy50%
mentions🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
related🔬What are the mechanisms underlying tdp-43 phase separation t50%
related🔬What are the mechanisms underlying astrocyte reactivity subt50%
related🔬What are the mechanisms underlying blood-brain barrier trans50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying apoe4 structural biology 50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying digital biomarkers and ai50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying neuroinflammation resolut50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying rna binding protein dysre50%
related🔬What are the mechanisms underlying synaptic pruning by micro50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬What are the mechanisms underlying epigenetic clocks and bio50%
related🔬What are the mechanisms underlying perivascular spaces and g50%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
related🔬What are the mechanisms underlying tdp-43 phase separation t50%
related🔬What are the mechanisms underlying astrocyte reactivity subt50%
related🔬What are the mechanisms underlying blood-brain barrier trans50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying apoe4 structural biology 50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying digital biomarkers and ai50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying neuroinflammation resolut50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬What are the mechanisms underlying protein aggregation cross50%
related🔬What are the mechanisms underlying mechanistic role of apoe 50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying sleep disruption as cause50%
related🔬What are the mechanisms underlying rna binding protein dysre50%
related🔬What are the mechanisms underlying synaptic pruning by micro50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬What are the mechanisms underlying epigenetic clocks and bio50%
related🔬What are the mechanisms underlying perivascular spaces and g50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬What gene expression changes in the aging mouse brain predic50%
related🔬What gene expression changes in the aging mouse brain predic50%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬Senescent cell clearance as neurodegeneration therapy50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬How does metabolic reprogramming (glucose metabolism shifts,50%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc50%
see_also📖BEACoN Study - Biomarker Exploration in Aging, Cognition and50%
see_also📖LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for APOE45%
see_also📖LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy for 45%
see_also📖nct0550878945%
see_also📖remternetug-anti-amyloid-alzheimers45%
see_also📖UPenn Observational Research Repository (NCT04715399)45%
see_also📖mTOR Signaling in Neurodegeneration45%
see_also📖mTOR Signaling Pathway in Neurodegeneration45%
mentions🔬Analyze circuit-level changes in neurodegeneration using All40%
related🧪APOE Isoform Conversion Therapy40%
related🧪Noradrenergic-Tau Propagation Blockade40%
related🧪Adenosine-Astrocyte Metabolic Reset40%
related🧪APOE-Mediated Synaptic Lipid Raft Stabilization40%
related🧪Proteostasis Enhancement via APOE Chaperone Targeting40%
related🧪Hypocretin-Neurogenesis Coupling Therapy40%
related🧪Orexin-Microglia Modulation Therapy40%
related🧪Sleep Spindle-Synaptic Plasticity Enhancement40%
related🧪Circadian Clock-Autophagy Synchronization40%
related🧪APOE4-Selective Lipid Nanoemulsion Therapy40%
related🧪Circadian Glymphatic Rescue Therapy (Melatonin-focused)40%
related🧪TREM2 Conformational Stabilizers for Synaptic Discrimination40%
related🧪Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration40%
related🧪HSP90-Tau Disaggregation Complex Enhancement40%
related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer40%
related🧪VCP-Mediated Autophagy Enhancement40%
related🧪SASP-Mediated Cholinergic Synapse Disruption40%
related🧪CYP46A1 Overexpression Gene Therapy40%
related🧪Metabolic Reprogramming via Microglial Glycolysis Inhibition40%
related🧪Astroglial Gap Junction Coordination via Connexin-43 Phospho40%
related🧪Metabolic Circuit Breaker via Lipid Droplet Modulation40%
related🧪AMPK hypersensitivity in astrocytes creates enhanced mitocho40%
related🧪Nutrient-Sensing Epigenetic Circuit Reactivation40%
related🧪SIRT6-NAD+ Axis Enhancement Therapy40%
related🧪Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics40%
related🧪SASP-Mediated Complement Cascade Amplification40%
related🧪Heat Shock Protein 70 Disaggregase Amplification40%
related🧪Autophagosome Maturation Checkpoint Control40%
related🧪Glymphatic System-Enhanced Antibody Clearance Reversal40%
related🧪Hypocretin-Neurogenesis Coupling Therapy40%
related🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation40%
related🧪Bacterial Enzyme-Mediated Dopamine Precursor Synthesis40%
related🧪Orexin-Microglia Modulation Therapy40%
related🧪Lysosomal Calcium Channel Modulation Therapy40%
related🧪Membrane Cholesterol Gradient Modulators40%
related🧪Metabolic Switch Targeting for A1→A2 Repolarization40%
related🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th40%
related🧪Transcriptional Autophagy-Lysosome Coupling40%
related🧪Digital Twin-Guided Metabolic Reprogramming40%
related🧪TREM2-mediated microglial tau clearance enhancement40%
related🧪Circadian Clock-Autophagy Synchronization40%
related🧪Ephrin-B2/EphB4 Axis Manipulation40%
related🧪Microbial Inflammasome Priming Prevention40%
related🧪Phase-Separated Organelle Targeting40%
related🧪Nucleolar Stress Response Normalization40%
related🧪Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution40%
related🧪Purinergic P2Y12 Inverse Agonist Therapy40%
related🔬Senescent cell clearance as neurodegeneration therapy40%
related🔬Senescent cell clearance as neurodegeneration therapy40%
related🔬What are the mechanisms underlying sleep disruption as cause40%
related🔬Sleep disruption as cause and consequence of neurodegenerati40%
mentions🔬What are the mechanisms underlying 4r-tau strain-specific sp35%
mentions🔬What are the mechanisms underlying tdp-43 phase separation t35%
mentions🔬What are the mechanisms underlying astrocyte reactivity subt35%
mentions🔬What are the mechanisms underlying blood-brain barrier trans35%
mentions🔬What are the mechanisms underlying microglia-astrocyte cross35%
mentions🔬What are the mechanisms underlying apoe4 structural biology 35%
mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa35%
mentions🔬What are the mechanisms underlying digital biomarkers and ai35%
mentions🔬What are the mechanisms underlying senolytic therapy for age35%
mentions🔬What are the mechanisms underlying neuroinflammation resolut35%
mentions🔬What are the mechanisms underlying what are the mechanisms b35%
mentions🔬What are the mechanisms underlying protein aggregation cross35%
mentions🔬Investigate how lipid raft composition (cholesterol metaboli35%
mentions🔬What are the mechanisms underlying sleep disruption as cause35%
mentions🔬What are the mechanisms underlying rna binding protein dysre35%
mentions🔬What are the mechanisms underlying synaptic pruning by micro35%
mentions🔬What are the mechanisms underlying mitochondrial transfer be35%
mentions🔬What are the mechanisms underlying epigenetic clocks and bio35%
mentions🔬What are the mechanisms underlying perivascular spaces and g35%
mentions🔬What gene expression changes in the aging mouse brain predic35%
mentions🔬What gene expression changes in the aging mouse brain predic35%
mentions🔬Epigenetic reprogramming in aging neurons35%
mentions🔬Investigate prion-like spreading of tau pathology through co35%
mentions🔬How does metabolic reprogramming (glucose metabolism shifts,35%
mentions🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas35%
related🔬Analysis question not specified30%
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