[Archived Hypothesis]

graph TD
    TREM2_DAP12_signaling["TREM2-DAP12 signaling"] -->|activates| PI3K_AKT_pathway["PI3K/AKT pathway"]
    TREM2_DAP12_signaling_1["TREM2-DAP12 signaling"] -->|activates| MAPK_pathway["MAPK pathway"]
    TREM2_deficiency["TREM2 deficiency"] -->|causes| impaired_microglial_clust["impaired microglial clustering around amyloid plaques"]
    TREM2_agonism["TREM2 agonism"] -->|activates| microglial_proliferation["microglial proliferation"]
    TREM2_agonism_2["TREM2 agonism"] -->|activates| microglial_activation["microglial activation"]
    TREM2_R47H_variant["TREM2 R47H variant"] -->|risk factor for| amyloid_related_imaging_a["amyloid-related imaging abnormalities"]
    microglial_dysfunction["microglial dysfunction"] -->|modulates| Alzheimer_s_disease["Alzheimer's disease"]
    microglial_dysfunction_3["microglial dysfunction"] -->|modulates| amyloid_toxicity["amyloid toxicity"]
    TREM2_knockout["TREM2 knockout"] -->|causes| spontaneous_neurodegenera["spontaneous neurodegeneration"]
    sess_hypdebate_h_af0ec8d8["sess_hypdebate_h_af0ec8d843_20260427_163202"] -->|causal extracted| processed["processed"]
    sess_hypdebate_h_44b1c9d4["sess_hypdebate_h_44b1c9d415_20260427_113719"] -->|causal extracted| processed_4["processed"]
    sess_legacy_pre_pipeline_["sess_legacy-pre-pipeline-import-v1_task_9aae8fc5"] -->|causal extracted| processed_5["processed"]
    style TREM2_DAP12_signaling fill:#81c784,stroke:#333,color:#000
    style PI3K_AKT_pathway fill:#81c784,stroke:#333,color:#000
    style TREM2_DAP12_signaling_1 fill:#81c784,stroke:#333,color:#000
    style MAPK_pathway fill:#81c784,stroke:#333,color:#000
    style TREM2_deficiency fill:#4fc3f7,stroke:#333,color:#000
    style impaired_microglial_clust fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_agonism fill:#4fc3f7,stroke:#333,color:#000
    style microglial_proliferation fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_agonism_2 fill:#4fc3f7,stroke:#333,color:#000
    style microglial_activation fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_R47H_variant fill:#ce93d8,stroke:#333,color:#000
    style amyloid_related_imaging_a fill:#4fc3f7,stroke:#333,color:#000
    style microglial_dysfunction fill:#4fc3f7,stroke:#333,color:#000
    style Alzheimer_s_disease fill:#ef5350,stroke:#333,color:#000
    style microglial_dysfunction_3 fill:#4fc3f7,stroke:#333,color:#000
    style amyloid_toxicity fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_knockout fill:#4fc3f7,stroke:#333,color:#000
    style spontaneous_neurodegenera fill:#4fc3f7,stroke:#333,color:#000
    style sess_hypdebate_h_af0ec8d8 fill:#4fc3f7,stroke:#333,color:#000
    style processed fill:#4fc3f7,stroke:#333,color:#000
    style sess_hypdebate_h_44b1c9d4 fill:#4fc3f7,stroke:#333,color:#000
    style processed_4 fill:#4fc3f7,stroke:#333,color:#000
    style sess_legacy_pre_pipeline_ fill:#4fc3f7,stroke:#333,color:#000
    style processed_5 fill:#4fc3f7,stroke:#333,color:#000