concept

PI3K/AKT PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

192Connections

0Hypotheses

0Analyses

44Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PI3K/AKT PATHWAY
Key Genes/Proteins	SYK, PDGF, CLU, BAX
Related Diseases	SEPSIS, METASTASIS

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PI3K_AKT_PATHWAY["PI3K/AKT PATHWAY"]
    style PI3K_AKT_PATHWAY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PI3K_AKT_PATHWAY -->|"mediates"| Cancer_Metabolism_Reprogrammin["Cancer Metabolism Reprogramming"]
    PI3K_AKT_PATHWAY -->|"promotes"| breast_cancer_drug_resistance(breast cancer drug resistance)
    PI3K_AKT_PATHWAY -->|"activates"| NRF2([NRF2])
    PI3K_AKT_PATHWAY -->|"phosphorylates"| GLUT1([GLUT1])
    PI3K_AKT_PATHWAY -->|"phosphorylates"| HK2["HK2"]
    PI3K_AKT_PATHWAY -->|"phosphorylates"| PKM2["PKM2"]
    PI3K_AKT_PATHWAY -->|"regulates"| Vascular_Barrier_Function(Vascular Barrier Function)
    PI3K_AKT_PATHWAY -->|"promotes"| TNBC_cell_proliferation["TNBC cell proliferation"]
    PI3K_AKT_PATHWAY -->|"causes"| Cancer_Metabolism(Cancer Metabolism)
    PI3K_AKT_PATHWAY -->|"regulates"| mTORC1([mTORC1])
    nomilin{"nomilin"} -.->|"inhibits"| PI3K_AKT_PATHWAY
    hesperetin{"hesperetin"} -->|"activates"| PI3K_AKT_PATHWAY
    SQDS{"SQDS"} -.->|"inhibits"| PI3K_AKT_PATHWAY
    PI3K_Inhibitor{"PI3K Inhibitor"} -.->|"inhibits"| PI3K_AKT_PATHWAY
    quinolinic_acid["quinolinic acid"] -->|"activates"| PI3K_AKT_PATHWAY
    ANGPT1([ANGPT1]) -->|"activates"| PI3K_AKT_PATHWAY
    TREM1["TREM1"] -->|"activates"| PI3K_AKT_PATHWAY
    REEP1([REEP1]) -->|"regulates"| PI3K_AKT_PATHWAY
    MYC([MYC]) -->|"regulates"| PI3K_AKT_PATHWAY
    TREM2([TREM2]) -->|"activates"| PI3K_AKT_PATHWAY

Outgoing (115)

Target	Relation	Type	Str
GLUCOSE METABOLISM	associated_with	concept	0.50
EXTRACELLULAR VESICLES	interacts_with	concept	0.50
QUERCETIN	inhibits	concept	0.50
SRPK1	regulates	concept	0.50
PI3K/AKT SIGNALING	activates	concept	0.50
NEURON	associated_with	cell_type	0.50
TAU	associated_with	protein	0.50
MACROPHAGES	associated_with	cell_type	0.50
MICROGLIA	associated_with	cell_type	0.50
AMYLOID	associated_with	protein	0.50
CELL SURVIVAL	associated_with	phenotype	0.50
MAPK	associated_with	gene	0.50
PDGF	associated_with	gene	0.50
ERK	associated_with	gene	0.50
INFLAMMATION	associated_with	phenotype	0.50
METASTASIS	associated_with	phenotype	0.50
QUERCETIN	associated_with	drug	0.45
PERICYTE	associated_with	cell_type	0.45
SEPSIS	associated_with	disease	0.45
AKT	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
TREM2	associated_with	gene	0.45
SYK	associated_with	gene	0.45
ANGIOGENESIS	associated_with	phenotype	0.45
GLIOMA	associated_with	disease	0.45
ASTROCYTES	associated_with	cell_type	0.45
PI3K	associated_with	gene	0.45
NRF2	associated_with	gene	0.45
STROKE	associated_with	disease	0.45
BDNF	associated_with	gene	0.45
MACROPHAGE	associated_with	cell_type	0.45
CLU	associated_with	gene	0.45
VALPROIC ACID	associated_with	drug	0.45
HDAC1	associated_with	gene	0.45
PSEN2	associated_with	gene	0.45
BAX	associated_with	gene	0.45
IRS1	associated_with	gene	0.45
DEPRESSION	associated_with	disease	0.45
SEMAGLUTIDE	associated_with	drug	0.45
CERAMIDE	associated_with	phenotype	0.45
MTOR	associated_with	gene	0.45
AXL	associated_with	gene	0.45
SODIUM BUTYRATE	associated_with	drug	0.45

Incoming (77)

Source	Relation	Type	Str
NEURON	stabilizes	cell_type	0.70
NEURON	treats	cell_type	0.70
NEURON	inhibits	cell_type	0.70
SYK	causes	gene	0.70
PDGF	causes	gene	0.70
SEPSIS	regulates	disease	0.65
SEPSIS	treats	disease	0.65
METASTASIS	regulates	phenotype	0.65
METASTASIS	interacts_with	phenotype	0.65
METASTASIS	activates	phenotype	0.65
ASTROCYTES	activates	cell_type	0.65
CLU	activates	gene	0.65
BAX	activates	gene	0.65
SODIUM BUTYRATE	regulates	drug	0.65
Pi3K	associated_with	pathway	0.50
cancer	associated_with	disease	0.50
Pi3K/Akt	associated_with	pathway	0.50
Pi3K	activates	pathway	0.50
cancer	activates	disease	0.50
Pi3K/Akt	activates	pathway	0.50
Pi3K	interacts_with	pathway	0.50
Pi3K/Akt	interacts_with	pathway	0.50
PERICYTE	interacts_with	concept	0.50
ANGPT1	interacts_with	concept	0.50
Sepsis	interacts_with	disease	0.50
ANGPT1	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
Sepsis	activates	disease	0.50
Pi3K	inhibits	pathway	0.50
Pi3K/Akt	inhibits	pathway	0.50
NEUROTOXICITY	activates	concept	0.50
Cognitive Impairment	activates	phenotype	0.50
apoptosis	activates	process	0.50
CELL PROLIFERATION	activates	concept	0.50
apoptosis	inhibits	process	0.50
Epithelial Cell	inhibits	cell_type	0.50
Nephropathy	inhibits	disease	0.50
Pi3K	expressed_in	pathway	0.50
Pi3K/Akt	expressed_in	pathway	0.50
NEURONS	expressed_in	concept	0.50
Pi3K	regulates	pathway	0.50
RHOA	regulates	gene	0.50
Pi3K/Akt	regulates	pathway	0.50
Glioma	regulates	disease	0.50
TREM2	activates	gene	0.50
DAP12	activates	protein	0.50
MICROGLIAL ACTIVATION	associated_with	phenotype	0.50
SYNAPTIC PLASTICITY	associated_with	phenotype	0.50
PANCREATIC CANCER	associated_with	disease	0.50
EPITHELIAL-MESENCHYMAL TRANSITION	associated_with	phenotype	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PI3K/AKT PATHWAY

Understanding Entity Pages

Wiki Pages (20)

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