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Species differences in pharmacology**: Why do many rodent TRPA1 antagonists fail in human trials? What structural differences underlie this?
active
open question
Created: 2026-04-25T20:29:34
By: backfill_open_questions
Quality:
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ID: open_question-83a45555-71de-49c1-9841-29
Open Question
open
Wiki: genes-trpa1
Species differences in pharmacology**: Why do many rodent TRPA1 antagonists fail in human trials? What structural differences underlie this?
Importance Elo
1500
Field Rank
Rank #1438 in genes
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page genes-trpa1
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Evidence Bearing On This Question
Animal Model Comparison for Neurodegenerative Disease Therapeutics
discriminating experiment · experiment · 90%
Development and validation of triple knock-in humanized mice
discriminating experiment · experiment · 85%
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▸Metadata
| status | open |
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-26T03:29:34.899830'} |
| field_tag | genes |
| source_id | genes-trpa1 |
| sub_field | trpa1 |
| source_kind | wiki |
| question_hash | 4c6a301714b9363971f35932fe9563056a72f559ae67c4c72df34ea481351bee |
| question_text | Species differences in pharmacology**: Why do many rodent TRPA1 antagonists fail in human trials? What structural differences underlie this? |
| importance_elo | 1500 |
| _schema_version | 1 |
| evidence_summary | Extracted from wiki page genes-trpa1 |
| evidence_xref_at | 2026-04-27T13:32:33.239650+00:00 |
| tractability_score | 0.5 |
| potential_impact_score | 0.5 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
3
0 supporting
0 contradicting
0 neutral
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