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Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging.
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ID: paper-30078711
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Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging.
["Goltsev Y", "Samusik N", "Kennedy-Darling J", "Bhate S", "Hale M", "Vazquez G", "Black S", "Nolan G"]
Abstract
A highly multiplexed cytometric imaging approach, termed co-detection by indexing (CODEX), is used here to create multiplexed datasets of normal and lupus (MRL/lpr) murine spleens. CODEX iteratively visualizes antibody binding events using DNA barcodes, fluorescent dNTP analogs, and an in situ polymerization-based indexing procedure. An algorithmic pipeline for single-cell antigen quantification in tightly packed tissues was developed and used to overlay well-known morphological features with de...
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