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The Circadian Clock, Nutritional Signals and Reproduction: A Close Relationship.
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ID: paper-36675058
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The Circadian Clock, Nutritional Signals and Reproduction: A Close Relationship.
Ono M, Ando H, Daikoku T, Fujiwara T, Mieda M, Mizumoto Y, Iizuka T, Kagami K, Hosono T, Nomura S, Toyoda N, Sekizuka-Kagami N, Maida Y, Kuji N, Nishi H, Fujiwara H
Abstract
The circadian rhythm, which is necessary for reproduction, is controlled by clock genes. In the mouse uterus, the oscillation of the circadian clock gene has been observed. The transcription of the core clock gene period (Per) and cryptochrome (Cry) is activated by the heterodimer of the transcription factor circadian locomotor output cycles kaput (Clock) and brain and muscle Arnt-like protein-1 (Bmal1). By binding to E-box sequences in the promoters of Per1/2 and Cry1/2 genes, the CLOCK-BMAL1 h...
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