Circadian locomotor activity-rest rhythm in Drosophila is regulated by microRNA-275.

The circadian clock in Drosophila generates the 24 hour (h) rhythmicity in its behavior. MicroRNAs are essential post-transcriptional regulators that can influence circadian rhythms by modulating clock mRNA expression or by aiding in the rhythmic oscillation of gene transcripts and their protein products. Previous studies identified around 27 miRNAs robustly expressed in Drosophila clock neurons. We conducted a genetic screen of 21 of these relatively underexplored miRNAs to investigate their ef...