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Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pathogenesis of polycystic ovary syndrome.
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Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pathogenesis of polycystic ovary syndrome.
Liu K, Hong Y, Gao Q, Huang J, Liu L, Li Y, Liang Y, Zhang S, He X, Nie X
Abstract
UNLABELLED: Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder and a major cause of female infertility. While epigenetic dysregulation, notably DNA methylation, has been recognized as a key driver of PCOS pathogenesis, the specific involvement of active demethylation mediated by Ten-Eleven Translocation (TET) enzymes in the onset of the disease is currently poorly understood. In order to explore the role of TET2-mediated 5-hydroxymethylcytosine (5hmC) modifications and the underlyi...
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