Epigenetic Memory Erasure via TET2 Activation

**Molecular Mechanism and Rationale** The fundamental basis of this therapeutic hypothesis centers on the epigenetic dysregulation that underlies astrocyte polarization in neurodegenerative diseases. Ten-eleven translocation methylcytosine dioxygenase 2 (TET2) serves as a critical epigenetic enzyme responsible for catalyzing the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), initiating active DNA demethylation processes. In the context of neurodegeneration, astrocytes un...