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Huangkui capsule mitigates diabetic nephropathy via epigenetic therapy effects.
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ID: paper-41815912
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Huangkui capsule mitigates diabetic nephropathy via epigenetic therapy effects.
["Yu Y", "Tang H", "Li N", "Ge H", "Wu J", "Gu H"]
Abstract
BACKGROUND: Huangkui capsule (HKC), a Chinese herbal medicine derived from Abelmoschus manihot (L.) ethanol extract, has clinical efficacy against diabetic nephropathy (DN). Our research group has actively engaged in exploring the efficacy of HKC in treating DN. The underlying pharmacological mechanisms have progressively become clearer but its epigenetic mechanisms remain unclear. OBJECTIVE: To elucidate HKC's epigenetic role in the treatment of DN. METHODS: Db/db mice (a type 2 diabetes/DN mod...
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