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Differences in mRNA expression of neuroinflammation-related genes in the temporal lobe of patients with drug-resistant focal epilepsy.
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ID: paper-41843422
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Differences in mRNA expression of neuroinflammation-related genes in the temporal lobe of patients with drug-resistant focal epilepsy.
Tan THL, McLean C, Christie M, Sanfilippo P, Drill M, Perucca P, Kwan P, O'Brien TJ, Monif M
Abstract
OBJECTIVES: Approximately one-third of epilepsy patients will not achieve seizure freedom with current antiseizure medications, and the identification of novel treatment targets is needed. We characterized alterations in neuroinflammation-related mRNA levels to aid in the identification of possible molecular mediators of DRTLE and discuss the potential for immunomodulatory therapies in this condition. METHODS: Temporal lobe samples from DRTLE and postmortem controls without neurological conditio...
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