📄
Exosome-transmitted microRNA-323a-3p participated in the occurrence of Hirschsprung's disease.
active
paper
Created:
By: unknown
Quality:
50%
✓ SciDEX
ID: paper-41906498
📄 Paper Details
Exosome-transmitted microRNA-323a-3p participated in the occurrence of Hirschsprung's disease.
Shen H, Wang C, Lv X, Gao Z, Qiu Y, Zhi Z, Tang J, Du C, Zhang R, Li H, Tang W
Abstract
BACKGROUND: Hirschsprung's disease (HSCR) is caused by defective enteric neural crest cell (ENCC) migration. Exosome-transmitted microRNAs are implicated in HSCR pathogenesis, but mechanisms remain unclear. METHODS: Plasma exosomes and colon tissues were collected from HSCR patients and controls. We assessed the effects of exosomal miR-323a-3p on the proliferation and migration of immortalized ENCC-derived neural cell line (iENC) in vitro using CCK-8, EdU and Transwell assays, and its impact on ...
▸Metadata
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.