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Clonal Hematopoiesis and Risk of Trastuzumab-Related Cardiotoxic Effects.
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ID: paper-41926089
📄 Paper Details
Clonal Hematopoiesis and Risk of Trastuzumab-Related Cardiotoxic Effects.
Park CS, Ryu G, Ahn HJ, Sun C, Lee SP, Kim HK, Kim YJ, Jeon SY, Lee HB, Moon HG, Han W, Lee DW, Lee KH, Han SW, Im SA, Lee SE, Jaiswal S, Koh Y, Park JB
Abstract
IMPORTANCE: Clonal hematopoiesis of indeterminate potential (CHIP) is linked to an increased incidence of cardiovascular and malignant diseases. OBJECTIVE: To determine whether CHIP is associated with cardiotoxic effects in patients with breast cancer receiving trastuzumab. DESIGN, SETTING, AND PARTICIPANTS: Analyses of human cohorts with complementary animal experimentation were performed using a nationwide population-based cohort (UK Biobank), 1 tertiary referral center (Seoul National Univers...
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