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Ketamine or Esketamine in Special Populations of Patients With Treatment-Resistant Depression.
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ID: paper-41935374
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Ketamine or Esketamine in Special Populations of Patients With Treatment-Resistant Depression.
Grabarczyk Ł, Wolfermann SR, Oniszczuk H, Radkowski P
Abstract
Conventional antidepressant drugs are effective in only approximately 50% of patients with treatment-resistant depression (TRD). Ketamine, a non-competitive N-methyl-D-aspartate receptor antagonist, offers a promising alternative with an exceptionally rapid antidepressant effect. Although its efficacy in the general TRD population is well established, its use in specific patient subpopulations warrants further investigation. We conducted a comprehensive, non-systematic review of preclinical and ...
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