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Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration.
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ID: paper-41949889
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Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration.
McEvoy LK, Zhang B, Nguyen S, Maihofer AX, Nievergelt CM et al.
Abstract
Epigenetic clocks of biological aging have been associated with cognitive impairment and dementia. Less is known about whether they are associated with an older-appearing brain or with an atrophy pattern associated with dementia. We examined associations of five epigenetic clocks measured at baseline with the Spatial Pattern of Atrophy for Recognition of Brain Aging (SPARE-BA) and the Alzheimer's Disease Pattern Similarity Score (AD-PS) derived from structural MRIs obtained an average of 8 years...
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