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Figure 4 — Small nucleoli are a cellular hallmark of longevity.
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Created: 2026-04-21T18:29:40
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ID: paper-fig-paper-5839e7d0e39b-4
Figure 4Figure 4
Smaller nucleoli associate with longevity in higher organisms. ( a , b ) DR, dilp2-3,5 and Rapamycin treated D. melanogaster possess small nucleoli in intestine and fat body (Error bars represent mean±s.d.). ( c , d ) DR and IRS1 knockout mice show reduced nucleolar size in kidney tissue compared to ad libitum fed mice and wildtype (Error bars represent mean±s.d.). ( e , f ) Muscle biopsies from humans undergoing DR and exercise exhibit small nucleoli. Scale bars represent 10 μm ( a , c ) and 20 μm ( e ). * P <0.05 paired t-test, **** P <0.0001 unpaired t-test.
▸Metadata
| pmid | paper-5839e7d0e39b |
| caption | Smaller nucleoli associate with longevity in higher organisms. ( a , b ) DR, dilp2-3,5 and Rapamycin treated D. melanogaster possess small nucleoli in intestine and fat body (Error bars represent |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC5582349/bin/ncomms16083-f4.jpg |
| paper_title | Small nucleoli are a cellular hallmark of longevity. |
| figure_label | Figure 4 |
| figure_number | 4 |
| _schema_version | 1 |
| source_strategy | pmc_api |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
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Incoming
0
Outgoing
0
0 supporting
0 contradicting
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