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Fig. 1 — TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocy
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Created: 2026-04-21T18:29:40
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Fig. 1Figure 2
Single-cell atlas of cardiac immune cells during sepsis progression. a , Schematic diagram showing scRNA-seq pipeline of murine cardiac immune cells during sepsis progression. SS, steady state. b , Uniform Manifold Approximation and Projection (UMAP) plots of 29,537 cardiac immune cells allocated into 15 clusters from the hearts of 14 WT mice at SS, 3, 7 and 21 d after CLP. Cardiac cells from 3–4 mice were mixed as one sample. c , UMAP plots of cardiac immune cells colored by cell type. d , Heat map showing selected cluster marker genes (top, color-coded by cluster and condition) with exemplar genes and cell-type annotation labeled. e , UMAP plots of cardiac immune cells from WT mice in different time points of sepsis, annotated by cell type as in c . Each time point is contributed by either three (SS or 21 d) or four mice (3 or 7 d). f , Bar plots showing the distribution of immune cell types from WT mice at different time points of sepsis (Extended Data Figs. 1 and 2 ). Sour
▸Metadata
| pmid | paper-eec8991d7498 |
| caption | Single-cell atlas of cardiac immune cells during sepsis progression. a , Schematic diagram showing scRNA-seq pipeline of murine cardiac immune cells during sepsis progression. SS, steady state. b , U |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC9886554/bin/42255_2022_715_Fig1_HTML.jpg |
| paper_title | TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis. |
| figure_label | Fig. 1 |
| figure_number | 2 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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