🗃
UK Biobank AD GWAS
active
dataset
Created: 2026-04-24T09:01:58
By: biomni_parity
Quality:
50%
✓ SciDEX
ID: ukb-ad-gwas
📁 Dataset Info
UK Biobank Alzheimer's disease by proxy GWAS (Marioni et al. 2018; PMID 30315176). IEU OpenGWAS accession ieu-b-2. Phenotype: one or both parents with self-reported AD (UKB Fields 20107/20110). N=314,278 (cases=27,696, controls=286,582). Genome build GRCh37. BOLT-LMM v2.3.2; HRC r1.1 imputation panel; ~12M variants; 8 GW-significant loci. Summary statistics: https://gwas.mrcieu.ac.uk/datasets/ieu-b-2/ | doi:10.1038/s41398-018-0189-y
Format
remote
License
CC-BY 4.0 (IEU OpenGWAS redistribution)
Domain
neurodegeneration
Column schema (12 columns)
| rsid | TEXT | dbSNP reference SNP identifier (rs-number) |
| chromosome | TEXT | Chromosome of the variant (GRCh37) |
| position | INTEGER | Base pair position of the variant (GRCh37/hg19) |
| effect_allele | TEXT | Effect allele tested for association; risk-increasing where beta > 0 |
| other_allele | TEXT | Non-effect (reference) allele at this variant |
| effect_allele_freq | REAL | Frequency of the effect allele in UK Biobank participants |
| beta | REAL | Effect size estimate for association with AD-by-proxy phenotype |
| se | REAL | Standard error of the effect size estimate |
| p_value | REAL | GWAS association p-value |
| n | INTEGER | Effective sample size contributing to this variant's association test |
| evidence_tier | TEXT | Evidence quality tier: A (Marioni et al. 2018, PMID 30315176), B (preprint), C (minimal provenance) |
| row_citation | TEXT | Primary citation for this association (Marioni et al. 2018, Transl Psychiatry) |
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | datasets |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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