Nicotinic Acetylcholine Alpha-6/Beta-2 Receptor Neurons
Introduction
<table class="infobox infobox-cell">
<tr>
<th class="infobox-header" colspan="2">Nicotinic Acetylcholine Alpha-6/Beta-2 Receptor Neurons</th>
</tr>
<tr>
<td class="label">Taxonomy</td>
<td>ID</td>
</tr>
<tr>
<td class="label">Cell Ontology (CL)</td>
<td>[CL:0000169](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000169)</td>
</tr>
<tr>
<td class="label">Database</td>
<td>ID</td>
</tr>
<tr>
<td class="label">Cell Ontology</td>
<td>[CL:0000169](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000169)</td>
</tr>
<tr>
<td class="label">Cell Ontology</td>
<td>[CL:0000197](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000197)</td>
</tr>
<tr>
<td class="label">Cell Ontology</td>
<td>[CL:0000789](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000789)</td>
</tr>
<tr>
<td class="label">Receptor Type</td>
<td>nAChR α6β2</td>
</tr>
<tr>
<td class="label">Family</td>
<td>Nicotinic acetylcholine</td>
</tr>
<tr>
<td class="label">Signaling Mechanism</td>
<td>Ligand-gated ion channel, selective for dopamine neurons</td>
</tr>
<tr>
<td class="label">Primary Location</td>
<td>Substantia nigra pars compacta, striatum, VTA</td>
</tr>
</table>
Nicotinic Acetylcholine Alpha 6 Beta 2 Receptor Neurons is an important cell type in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
Mermaid diagram (expand to render)
Nicotinic Acetylcholine Alpha-6/Beta-2 Receptor Neurons are neurons expressing the nAChR alpha6beta2 receptor, a member of the Nicotinic acetylcholine receptor family. These receptor neurons play crucial roles in dopamine release modulation, motor control and are implicated in various neurological and neurodegenerative conditions. [@nicotinic]
<!-- taxonomy-enrichment --> [@receptor]
<!-- multi-taxonomy-enrichment -->
Multi-Taxonomy Classification
Taxonomy Database Cross-References
PanglaoDB Marker Cross-References
External Database Links
- [Cell Ontology (CL:0000169)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000169)
- [OBO Foundry (CL:0000169)](http://purl.obolibrary.org/obo/CL_0000169)
- [Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
- [CellxGene Census](https://cellxgene.cziscience.com/)
- [Human Cell Atlas](https://www.humancellatlas.org/)
- [PanglaoDB](https://panglaodb.se/)
Taxonomy & Classification
PanglaoDB Marker Cross-References
External Database Links
- [Cell Ontology (CL:0000169)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000169)
- [OBO Foundry (CL:0000169)](http://purl.obolibrary.org/obo/CL_0000169)
- [Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
- [CellxGene Census](https://cellxgene.cziscience.com/)
- [PanglaoDB](https://panglaodb.se/)
Receptor Properties
Function
Nicotinic Acetylcholine Alpha-6/Beta-2 Receptor Neurons are involved in Dopamine release modulation, motor control. These neurons express the nAChR α6β2 receptor which ligand-gated ion channel, selective for dopamine neurons. The receptor's location in substantia nigra pars compacta, striatum, vta allows it to modulate neurotransmission and cellular signaling in key brain regions.
Signaling Pathway
The nAChR α6β2 receptor signals through ligand-gated ion channel, selective for dopamine neurons. This mechanism allows rapid or modulatory responses depending on the cellular context and co-expression of other receptors.
Disease Implications
Implicated in Parkinson's disease, dyskinesias. Understanding the role of these receptor neurons provides insight into potential therapeutic targets for these conditions.
Therapeutic Targets
The nAChR α6β2 receptor is a target for drug development in:
- Neurological disorders
- Neuropsychiatric conditions
- Neurodegenerative diseases
- Receptor Neurons
- Neurotransmitter Systemsmechanisms/cholinergic-hypothesis-ad)
- Nicotinic acetylcholine Signaling
Background
The study of Nicotinic Acetylcholine Alpha 6 Beta 2 Receptor Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
External Links
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
- [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
- [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data
References
nicotinic, Nicotinic acetylcholine receptor pharmacology
proteincoupled, G protein-coupled receptor signaling in neurons
receptor, Receptor neurons in neurodegenerative disease
Pathway Diagram
The following diagram shows the key molecular relationships involving Nicotinic Acetylcholine Alpha-6/Beta-2 Receptor Neurons discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)