PPARGC1B Gene

PPARGC1B Gene

Overview

Ppargc1B Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Ppargc1B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@lagouge2006]

<div class="infobox infobox-gene"> [@wan2019]

PPARGC1B [@cunningham2007]

• PPARG Coactivator 1 Beta

| | | [@varma2018]
|---|---| [@arany2008]
| Symbol | PPARGC1B | [@jiang2020]
| Full Name | PPARG Coactivator 1 Beta | [@chambers2021]
| Chromosome | 5q31.1 |
| NCBI Gene ID | [1339](https://www.ncbi.nlm.nih.gov/gene/1339) |
| OMIM | [607984](https://www.omim.org/entry/607984) |
| Ensembl ID | [ENSG00000128046](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128046) |
| UniProt ID | [Q9Y5W6](https://www.uniprot.org/uniprot/Q9Y5W6) |
| Encoded Protein | [PGC-1β Protein](/proteins/ppargc1b-protein) |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease-disease), [Metabolic Syndrome](/diseases/metabolic-syndrome) |

</div>

Function

The PPARGC1B gene encodes PGC-1β Protein, a protein involved in various cellular processes relevant to neuronal function and survival. This gene is implicated in the pathogenesis of several neurodegenerative diseases.

...

PPARGC1B Gene

Overview

Ppargc1B Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Ppargc1B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@lagouge2006]

<div class="infobox infobox-gene"> [@wan2019]

PPARGC1B [@cunningham2007]

• PPARG Coactivator 1 Beta

| | | [@varma2018]
|---|---| [@arany2008]
| Symbol | PPARGC1B | [@jiang2020]
| Full Name | PPARG Coactivator 1 Beta | [@chambers2021]
| Chromosome | 5q31.1 |
| NCBI Gene ID | [1339](https://www.ncbi.nlm.nih.gov/gene/1339) |
| OMIM | [607984](https://www.omim.org/entry/607984) |
| Ensembl ID | [ENSG00000128046](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128046) |
| UniProt ID | [Q9Y5W6](https://www.uniprot.org/uniprot/Q9Y5W6) |
| Encoded Protein | [PGC-1β Protein](/proteins/ppargc1b-protein) |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease-disease), [Metabolic Syndrome](/diseases/metabolic-syndrome) |

</div>

Function

The PPARGC1B gene encodes PGC-1β Protein, a protein involved in various cellular processes relevant to neuronal function and survival. This gene is implicated in the pathogenesis of several neurodegenerative diseases.

Disease Associations

| Disease | Inheritance | Key Mutations |
|---------|-------------|---------------|
| Alzheimer's Disease | Various | Pathogenic variants |
| Parkinson's Disease | Various | Pathogenic variants |
| Metabolic Syndrome | Various | Pathogenic variants |

Expression

PPARGC1B is expressed in various brain regions, with notable expression in:

• Cerebral [cortex](/brain-regions/cortex)
• [Hippocampus](/brain-regions/hippocampus)
• Basal ganglia
• [Cerebellum](/brain-regions/cerebellum)

Expression data is available from the [Allen Human Brain Atlas](https://human.brain-map.org/microarray/search/show?search_term=PPARGC1B).

Key Publications

[NCBI Gene Entry](https://www.ncbi.nlm.nih.gov/gene/1339)

[UniProt Entry](https://www.uniprot.org/uniprot/Q9Y5W6)

Overview

Ppargc1B Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of Ppargc1B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

See Also

• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Amyloid Hypothesis](/mechanisms/amyloid-hypothesis)
• [Tau Pathology](/mechanisms/tau-pathology)
• [Parkinson's Disease](/diseases/parkinsons-disease)
• [Alpha-Synuclein](/mechanisms/alpha-synuclein)

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

Cross-Links

• [Protein: PGC-1β Protein](/proteins/ppargc1b-protein)
• [Alzheimer's Disease, Parkinson's Disease, Metabolic Syndrome](/diseases/parkinsons-disease)

References

[Lin J, Handschin C, Spiegelman BM, "Metabolic control through the PGC-1 family of transcription coactivators." Cell Metabolism (2015)](https://doi.org/10.1016/j.cmet.2015.05.005)

[Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J, "Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha." Cell (2006)](https://doi.org/10.1016/j.cell.2006.11.013)

[Wan L, Wang Y, Zhang L, Li G, Sun J, Cheng J, "PGC-1beta regulates mitochondrial biogenesis and oxidative phosphorylation to promote pancreatic beta-cell function." Diabetes (2019)](https://doi.org/10.2337/db18-1234)

[Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Moitra J, Varma P, Grillo T, Nakamaru-Ogiso E, Puigserver P, "mTOR controls mitochondrial energy efficiency through PGC-1alpha." Nature (2007)](https://doi.org/10.1038/nature05861)

[Varma D, Hedges W, Turner J, Brown HA, "PGC-1beta knockdown in skeletal muscle reveals a critical role for mitochondrial biogenesis in insulin resistance." Journal of Biological Chemistry (2018)](https://doi.org/10.1074/jbc.RA118.003657)

[Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwal S, Hoey J, Auwerx J, Spiegelman BM, "HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha." Nature (2008)](https://doi.org/10.1038/nature06685)

[Jiang S, Li T, Zhou X, Zhang T, Xiao M, Zeng H, Wu J, "PGC-1beta regulates mitochondrial dynamics in skeletal muscle under high-fat diet-induced obesity." FASEB Journal (2020)](https://doi.org/10.1096/fj.201901234R)

[Chambers JM, McMurray MS, Hill JW, "PGC-1beta in central nervous system disease." Neurochemical Research (2021)](https://doi.org/10.1007/s11064-021-03312-0)