Dlg Associated Protein 1 (Sapap1) (Dlgap1 Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [@zhu2016] title: DLGAP1 Protein [@sala2019] description: DLG Associated Protein 1 (SAPAP1) - Scaffolding protein in PSD, organizes synaptic protein complexes, anchors receptors [^4] tags: protein, neurodegeneration, SAPAP family [^5] .infobox.inbox-protein [@sapap] DLGAP1 Protein [@dlgap] === === Protein Name: DLG Associated Protein 1 (SAPAP1) Gene: [DLGAP1](/proteins/dlgap1-protein) UniProt ID: O75178 Molecular Weight: 99 kDa Protein Family: SAPAP family Subcellular Localization: Postsynaptic density === ===
Overview
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DLG Associated Protein 1 (SAPAP1) (DLGAP1 Protein)
Dlg Associated Protein 1 (Sapap1) (Dlgap1 Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [@zhu2016] title: DLGAP1 Protein [@sala2019] description: DLG Associated Protein 1 (SAPAP1) - Scaffolding protein in PSD, organizes synaptic protein complexes, anchors receptors [^4] tags: protein, neurodegeneration, SAPAP family [^5] .infobox.inbox-protein [@sapap] DLGAP1 Protein [@dlgap] === === Protein Name: DLG Associated Protein 1 (SAPAP1) Gene: [DLGAP1](/proteins/dlgap1-protein) UniProt ID: O75178 Molecular Weight: 99 kDa Protein Family: SAPAP family Subcellular Localization: Postsynaptic density === ===
Overview
DLG Associated Protein 1 (SAPAP1) is a protein encoded by the [DLGAP1](/proteins/dlgap1-protein) gene. It belongs to the SAPAP family and is primarily localized to Postsynaptic density.
Structure
DLGAP1 is a 99 kDa protein with multiple domains that enable its scaffolding and signaling functions in [neurons](/entities/neurons).
Normal Function
Scaffolding protein in PSD, organizes synaptic protein complexes, anchors receptors. This protein plays important roles in maintaining normal neuronal function and synaptic transmission.
Role in Neurodegeneration
Alterations in DLGAP1 have been associated with several neurodegenerative and neurological disorders. Studies have shown changes in expression and mutations in various disease contexts.
Therapeutic Targeting
Research is ongoing to develop therapeutic approaches targeting DLGAP1 for neurological disorders.
Correlates with cognitive decline in neurodegeneration
Animal Models
Knockout mice: Show learning and memory deficits
Transgenic models: Overexpression leads to enhanced [LTP](/mechanisms/long-term-potentiation)
Behavioral studies: Altered social interaction and anxiety
Research Directions
Single-cell sequencing of DLGAP1-expressing neurons
Proteomic studies of PSD interactions
Development of [blood-brain barrier](/entities/blood-brain-barrier) permeable compounds
Background
The study of Dlg Associated Protein 1 (Sapap1) (Dlgap1 Protein) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
[@sapap]: PMID: 26168996(https://pubmed.ncbi.nlm.nih.gov/26168996/) - SAPAP mutations in neurodevelopmental disorders [@dlgap]: PMID: 38000301(https://pubmed.ncbi.nlm.nih.gov/38000301/) - DLGAP1 in synaptic organization and neurological disorders