Gsk3A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Gsk3A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
GSK3A (GSK3A) is a serine/threonine-protein kinase that plays critical roles in neuronal signal transduction, synaptic plasticity, and protein phosphorylation. It is a key therapeutic target for Alzheimer's disease and other neurodegenerative disorders, with roles in [tau](/proteins/tau) phosphorylation, neuroinflammation, and cell survival pathways. [@gsk]
GSK3A is a serine/threonine-protein kinase belonging to the glycogen synthase kinase (GSK) family. It plays critical roles in neuronal signal transduction, synaptic plasticity, and [tau](/proteins/tau) phosphorylation in Alzheimer's disease. [@tau]
Protein Information
Structure
Domain Architecture
N-terminal Domain (aa 1-80): Flexible regulatory domain unique to GSK3A
The study of Gsk3A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
[Unknown, GSK3A in neuronal signaling and Alzheimer's disease (n.d.)](https://pubmed.ncbi.nlm.nih.gov/11146001/)
[Unknown, GSK3 family kinases in neurodegeneration: mechanisms and therapeutic potential (n.d.)](https://pubmed.ncbi.nlm.nih.gov/20801953/)
[Unknown, Tau phosphorylation by GSK3 isoforms in Alzheimer's disease pathogenesis (n.d.)](https://pubmed.ncbi.nlm.nih.gov/25683225/)
[Unknown, Targeting GSK3 for neuroprotection in neurodegenerative diseases (n.d.)](https://pubmed.ncbi.nlm.nih.gov/23590537/)
[Unknown, Lithium inhibition of GSK3 activity and therapeutic applications (n.d.)](https://pubmed.ncbi.nlm.nih.gov/18691221/)
[Unknown, GSK3 inhibitors in clinical trials for AD and related disorders (n.d.)](https://pubmed.ncbi.nlm.nih.gov/29139379/)
Unknown, Synaptic plasticity by GSK3 isoforms (n.d.)
[Unknown, Neuroinflammation and GSK3 signaling in neurodegeneration (n.d.)](https://pubmed.ncbi.nlm.nih.gov/22875936/)