CDK5 Protein (Cyclin-Dependent Kinase 5)

CDK5 Protein (Cyclin-Dependent Kinase 5)

Overview

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">CDK5 Protein (Cyclin-Dependent Kinase 5)</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>Q00535</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>CDK5 (Cyclin-Dependent Kinase 5)</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Protein</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/?query=Q00535" target="_blank">Search UniProt</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

[Cdk5](/genes/cdk5) Protein (Cyclin Dependent Kinase 5) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

[Cdk5](/genes/cdk5) Protein (Cyclin Dependent Kinase 5) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@cdk2011]

CDK5 Protein (Cyclin-Dependent Kinase 5)

Overview

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">CDK5 Protein (Cyclin-Dependent Kinase 5)</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>Q00535</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>CDK5 (Cyclin-Dependent Kinase 5)</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Protein</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/?query=Q00535" target="_blank">Search UniProt</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

[Cdk5](/genes/cdk5) Protein (Cyclin Dependent Kinase 5) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

[Cdk5](/genes/cdk5) Protein (Cyclin Dependent Kinase 5) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@cdk2011]

.infobox-protein [@cdk2002]
!! colspan="2" style="background:#f8f9fa; text-align:center; font-weight:bold" | [CDK5](/genes/cdk5) Protein (Cyclin-Dependent Kinase 5) [@cdkp1999]
|- [@cdk2014]
! Gene [@cdk1999]
| [CDK5](/genes/cdk5) [@cdk2011a]
|- [@cdk2013]
! UniProt
| [Q00535](https://www.uniprot.org/uniprot/Q00535)
|-
! PDB Structures
| 1H4L, 3O0G, 4AU8, 5HPJ
|-
! Molecular Weight
| ~33 kDa
|-
! Subcellular Localization
| Neuronal cell body, synapses, cytoskeleton
|-
! Protein Family
| Serine/Threonine Kinase
|-

Structure

[CDK5](/proteins/cdk5) is a proline-directed serine/threonine kinase that requires association with regulatory subunits p35 or p39 for activity. The kinase domain shares homology with other CDKs but has unique structural features that determine its neuronal specificity.

Normal Function

CDK5 is critical for neuronal development and function. It regulates neuronal migration, axonal guidance, synapse formation, and plasticity. CDK5 phosphorylates numerous substrates including [tau](/proteins/tau), synapsin, NMDA and AMPA receptor subunits, and transcription factors. It is essential for learning and memory.

Role in Disease

Dysregulated CDK5 activity contributes to neurodegeneration. In AD, CDK5 hyperphosphorylates tau and is activated by [A-beta](/proteins/amyloid-beta). In PD, CDK5 can phosphorylate [alpha-synuclein](/proteins/alpha-synuclein) and contribute to dopaminergic neuron death. In ALS, CDK5 is involved in motor neuron degeneration. p25 accumulation (truncated p35) leads to CDK5 hyperactivation in neurodegeneration.

Therapeutic Targeting

CDK5 inhibitors have been explored but face challenges due to its essential functions. Roscovitine (seliciclib) inhibits CDK5 among other CDKs. Peptide inhibitors targeting CDK5-p25 interaction are in development.Gene therapy approaches to reduce p25 are being investigated.

Key Publications

Overview

Cdk5 Protein (Cyclin Dependent Kinase 5) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of Cdk5 Protein (Cyclin Dependent Kinase 5) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

See Also

• [CDK5 Gene](/genes/cdk5)
• [Proteins/Q00535](/proteins/Q00535)

References