RPA1 Protein

RPA1 Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">RPA1 Protein</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>Replication Protein A1 (RPA1)</td>
</tr>
<tr>
<td class="label">Gene</td>
<td>[RPA1](/genes/rpa1)</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td>[P27694](https://www.uniprot.org/uniprot/P27694)</td>
</tr>
<tr>
<td class="label">PDB Structure</td>
<td>1JMC, 1L1O, 1L2N</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~70 kDa</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Nucleus</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>RPA family</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/lymphoma" style="color:#ef9a9a">Lymphoma</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">11 edges</a></td>
</tr>
</table>

Rpa1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

--- [@rpa2005]
title: RPA1 Protein [@rpa2018]
--- [@rpa2010]

:: infobox .infobox-protein [@dna2019]
::

Overview

RPA1 Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">RPA1 Protein</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>Replication Protein A1 (RPA1)</td>
</tr>
<tr>
<td class="label">Gene</td>
<td>[RPA1](/genes/rpa1)</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td>[P27694](https://www.uniprot.org/uniprot/P27694)</td>
</tr>
<tr>
<td class="label">PDB Structure</td>
<td>1JMC, 1L1O, 1L2N</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~70 kDa</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Nucleus</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>RPA family</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/lymphoma" style="color:#ef9a9a">Lymphoma</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">11 edges</a></td>
</tr>
</table>

Rpa1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

--- [@rpa2005]
title: RPA1 Protein [@rpa2018]
--- [@rpa2010]

:: infobox .infobox-protein [@dna2019]
::

Overview

Replication Protein A1 (RPA1) is the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which is essential for DNA replication, repair, and recombination. RPA1 serves as the primary ssDNA-binding subunit and coordinates multiple DNA metabolic processes through protein-protein interactions with various DNA repair factors. In [neurons](/entities/neurons), RPA1 plays critical roles in maintaining genomic stability through its involvement in multiple DNA repair pathways.

Structure

RPA1 is a 639-amino acid protein with multiple functional domains. The N-terminal domain contains a high-affinity ssDNA-binding domain (DBD-A), followed by DBD-B, DBD-C, and a C-terminal DBD-D. The protein also contains interaction domains for various repair proteins including RAD51, ATR, and p53.

Normal Function

RPA1 is the core component of the RPA complex, which binds to ssDNA during DNA replication, repair, and recombination. It prevents secondary structure formation in ssDNA and coordinates the assembly of DNA repair complexes at damage sites.

In neurons, RPA1 is involved in maintaining genomic stability through its roles in nucleotide excision repair (NER), base excision repair (BER), and homologous recombination (HR). These functions are particularly important in post-mitotic neurons that cannot rely on cell division to eliminate damaged DNA.

Role in Disease

Alzheimer's Disease

RPA1-mediated DNA repair may be impaired in AD. DNA damage accumulation is a hallmark of AD brains, and RPA1 dysfunction could contribute to neuronal genome instability.

Parkinson's Disease

DNA repair defects, including impaired RPA1 function, may contribute to dopaminergic neuron vulnerability in PD.

Ataxia-Telangiectasia

While ATM kinase directly regulates RPA1 phosphorylation after DNA damage, RPA1 dysfunction can exacerbate AT phenotypes.

Therapeutic Targeting

No RPA1-targeted therapies exist. Enhancing DNA repair capacity is a therapeutic strategy being explored for neurodegenerative diseases.

Key Publications

Background

The study of Rpa1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

Cross-Links

• RPA1 Gene
• [RPA2 Protein](/proteins/rpa2-protein)
• [DNA Repair Pathways](/mechanisms/dna-damage-response-neurodegeneration) [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)
• Genomic Stability

See Also

• DNA Replication
• [DNA Repair Mechanisms](/mechanisms/dna-damage-response)
• Base Excision Repair
• [Neurodegeneration Overview](/diseases/neurodegeneration)

References