Timm8A Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Timm8A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@koehler1998]
TIMM8A (Translocase of Inner Mitochondrial Membrane Subunit 8A) is a small mitochondrial intermembrane space chaperone protein that facilitates the import of nuclear-encoded proteins into the mitochondria. It partners with TIMM13 to form a heterohexameric complex that guides hydrophobic proteins across the intermembrane space. [@hofmann2002]
Protein Overview
Structure
Domain Architecture
Twin CX3C Motif: Characteristic of small TIM proteins
Disulfide Bonds: Two intramolecular disulfide bonds stabilize structure
Koehler CM, et al. (1999). "The small Tim proteins facilitate the import of carrier proteins into mitochondria." Nature. PMID: 10517498(https://pubmed.ncbi.nlm.nih.gov/10517498/)
Herrmann JM, et al. (2013). "Biogenesis of the mitochondrial intermembrane space." Biochim Biophys Acta. PMID: 23603797(https://pubmed.ncbi.nlm.nih.gov/23603797/)
Deschauer M, et al. (2004). "A splice site mutation in TIMM8A causing isolated deafness-dystonia syndrome." Neurology. PMID: 15956176(https://pubmed.ncbi.nlm.nih.gov/15956176/)
Taylor SW, et al. (2004). "Characterization of the human mitochondrial protein import machinery." J Mol Biol. PMID: 15560828(https://pubmed.ncbi.nlm.nih.gov/15560828/)
Weinhäupl K, et al. (2018). "Structure of the TIM8/TIM13 complex." J Mol Biol. PMID: 29588123(https://pubmed.ncbi.nlm.nih.gov/29588123/)
Overview
Timm8A Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Timm8A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.