<table class="infobox infobox-researcher">
<tr>
<th class="infobox-header" colspan="2">Reisa A. Sperling</th>
</tr>
<tr>
<td class="infobox-image" colspan="2">
<em>Photo placeholder</em>
</td>
</tr>
<tr>
<td class="label">Affiliations</td>
<td>Brigham and Women's Hospital<br>Harvard Medical School</td>
</tr>
<tr>
<td class="label">Country</td>
<td>USA</td>
</tr>
<tr>
<td class="label">H-index</td>
<td>200</td>
</tr>
<tr>
<td class="label">ORCID</td>
<td><a href="https://orcid.org/0000-0001-5571-3614" target="_blank">0000-0001-5571-3614</a></td>
</tr>
<tr>
<td class="label">Research Focus</td>
<td>[Alzheimer's Disease](/diseases/alzheimers)</td>
</tr>
<tr>
<td class="label">Mechanisms</td>
<td>[Biomarkers](/mechanisms/biomarkers-ad), [Amyloid](/mechanisms/amyloid-cascade), Prevention</td>
</tr>
</table>
Reisa A. Sperling
Overview
Reisa A. Sperling is a leading researcher in the field of neurodegenerative diseases, affiliated with Brigham and Women's Hospital and Harvard Medical School. Their research focuses on Biomarkers, Amyloid, Prevention, with particular emphasis on Alzheimer's Disease. With an h-index of 200, Sperling is among the most cited researchers in the neuroscience field[@orcid2026].
...<table class="infobox infobox-researcher">
<tr>
<th class="infobox-header" colspan="2">Reisa A. Sperling</th>
</tr>
<tr>
<td class="infobox-image" colspan="2">
<em>Photo placeholder</em>
</td>
</tr>
<tr>
<td class="label">Affiliations</td>
<td>Brigham and Women's Hospital<br>Harvard Medical School</td>
</tr>
<tr>
<td class="label">Country</td>
<td>USA</td>
</tr>
<tr>
<td class="label">H-index</td>
<td>200</td>
</tr>
<tr>
<td class="label">ORCID</td>
<td><a href="https://orcid.org/0000-0001-5571-3614" target="_blank">0000-0001-5571-3614</a></td>
</tr>
<tr>
<td class="label">Research Focus</td>
<td>[Alzheimer's Disease](/diseases/alzheimers)</td>
</tr>
<tr>
<td class="label">Mechanisms</td>
<td>[Biomarkers](/mechanisms/biomarkers-ad), [Amyloid](/mechanisms/amyloid-cascade), Prevention</td>
</tr>
</table>
Reisa A. Sperling
Overview
Reisa A. Sperling is a leading researcher in the field of neurodegenerative diseases, affiliated with Brigham and Women's Hospital and Harvard Medical School. Their research focuses on Biomarkers, Amyloid, Prevention, with particular emphasis on Alzheimer's Disease. With an h-index of 200, Sperling is among the most cited researchers in the neuroscience field[@orcid2026].
Sperling's work spans multiple aspects of neurodegeneration, contributing to our understanding of the molecular mechanisms that underlie diseases such as Alzheimer's Disease. Their research group has made significant contributions to the fields of Biomarkers, Amyloid, Prevention, publishing in high-impact journals including Alzheimers Dement.
Based at Brigham and Women's Hospital and Harvard Medical School, Sperling collaborates with researchers across multiple institutions worldwide, working to advance therapeutic strategies for neurodegenerative conditions.
Research Focus
Disease Areas
- [Alzheimer's Disease](/diseases/alzheimers-disease)
Mechanisms of Interest
- [Biomarkers](/mechanisms/biomarkers-ad)
- [Amyloid](/mechanisms/amyloid-cascade)
- Prevention
Programmatic Emphasis
Sperling's portfolio emphasizes mechanism-aware biomarker interpretation and translational hypothesis testing in Alzheimer's Disease[@long2019]. Their group typically links molecular process readouts to clinically meaningful outcomes, including cognitive trajectories, motor phenotypes, and disease staging endpoints when relevant.
The work frequently sits at the interface of discovery science and implementation, using study designs that can be transferred from observational cohorts to interventional studies. This makes the profile especially relevant for NeuroWiki pages that connect molecular mechanisms to treatment strategy, trial design, and patient stratification.
Methods and Data Strategy
Within the Biomarkers, Amyloid, Prevention domain, this research profile is most aligned with multimodal integration: combining imaging, biofluid, genomic, and clinical metadata to derive robust disease signatures. In practice, this means prioritizing reproducibility (cohort harmonization, independent replication, and transparent analysis assumptions) over one-off findings.
The program also supports comparative interpretation across related disorders, helping distinguish disease-general stress biology from disease-specific pathomechanisms. That distinction is important for mechanistic ranking and for selecting therapeutic targets with realistic translational potential.
Translational Relevance
For NeuroWiki readers, the translational value of this researcher profile lies in three areas: first, operationalizing mechanism-informed biomarkers for diagnosis and progression tracking; second, identifying patient subgroups most likely to respond to targeted interventions; and third, connecting preclinical hypotheses to trial-ready outcome frameworks.
This orientation improves actionability of mechanistic knowledge graphs because it links entities and pathways to measurable clinical decisions. Pages connected to this profile should therefore prioritize explicit mechanism-to-outcome chains, with clear assumptions and evidence quality labels.
Key Publications
[Toward defining the preclinical stages of Alzheimer's disease](https://doi.org/10.1016/j.jalz.2011.03.003). Alzheimers Dement, 2011.[@toward2011]
Recent Research
Recent PubMed-indexed publications (2025-present):
[Cognitive screening biases in a secondary prevention Alzheimer's disease clinical trial.](https://pubmed.ncbi.nlm.nih.gov/41778849/). Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026.
[Sex Differences in P-Tau217, Tau Aggregation, and Cognitive Decline.](https://pubmed.ncbi.nlm.nih.gov/41697669/). JAMA neurology. 2026.
[AI-enhanced Centiloid quantification of amyloid PET images.](https://pubmed.ncbi.nlm.nih.gov/41670187/). Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026.
[Cognitive screening biases in a secondary prevention Alzheimer's disease clinical trial.](https://pubmed.ncbi.nlm.nih.gov/41409674/). medRxiv : the preprint server for health sciences. 2025.
Collaborators and Research Network
[Dennis J. Selkoe](/researchers/dennis-selkoe), [Eric M. Reiman](/researchers/eric-reiman), [Paul S. Aisen](/researchers/paul-aitken), [Kristine Yaffe](/researchers/kristine-yaffe)
Institutional Context
Primary institutional links: [Brigham and Women's Hospital](/institutions/brigham-and-women's-hospital), [Harvard Medical School](/institutions/harvard-medical-school). These organizations provide critical infrastructure for longitudinal cohorts, mechanistic phenotyping, and translational trial partnerships in neurodegeneration research.
Open Questions and Future Directions
- How can Biomarkers, Amyloid, Prevention signals be standardized across cohorts and sites without losing disease-stage sensitivity?
- Which biomarker combinations best separate causal mechanism activity from downstream epiphenomena?
- What trial designs can most efficiently translate mechanistic findings in Alzheimer's Disease into clinically meaningful interventions?
External Links
- ORCID: [https://orcid.org/0000-0001-5571-3614](https://orcid.org/0000-0001-5571-3614)
- Google Scholar: [Search for Reisa A. Sperling](https://scholar.google.com/scholar?q=author%3A%22Reisa+A.+Sperling%22)
- PubMed: [Author search for Reisa A. Sperling](https://pubmed.ncbi.nlm.nih.gov/?term=Reisa+A.+Sperling%5BAuthor%5D)
See Also
- [Researchers and Institutions Index](/researchers)
- [Diseases Index](/diseases)
- [Mechanisms Index](/mechanisms)
References
[Unknown, Toward defining the preclinical stages of Alzheimer's disease (2011)](https://doi.org/10.1016/j.jalz.2011.03.003)
Unknown, ORCID profile for Reisa A. Sperling (2026)
[Unknown, Long and Holtzman, Alzheimer disease an update on pathobiology and treatment strategies 2019 (2019)](https://pubmed.ncbi.nlm.nih.gov/30617256/)