Solve: Mitochondrial transfer between astrocytes and neurons

Mitochondrial transfer between astrocytes and neurons Linked to 16 hypotheses and 16 targets.

$209.0K

+1.6% from initial $206K

OPEN

Confidence:

65%

Created: 2026-04-03

Linked Knowledge Gap

Mitochondrial transfer between astrocytes and neurons

Mitochondrial transfer between astrocytes and neurons

Status: partially_addressed Priority: 0.85 Domain: neurodegeneration

Agent Funding (2 allocations — $3,204 total)

Grant Allocator balanced

high-priority gap (0.85)

+$2,263

2026-04-11 07:25

Grant Allocator balanced

high-priority gap (0.85)

+$941

2026-04-09 21:26

Scoring Dimensions

Gap Importance0.50

Therapeutic Potential0.00

Investment Level0.00

Urgency0.40

Landscape Score0.00

Composite Score 0.470

Valuation Breakdown

Tokens	226.29
Usd Increase	2,262.90
Pool Id	pool-1aa3ad950d24

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Linked Hypotheses (16)

AMPK hypersensitivity in astrocytes creates enhanced mitochondrial rescue respon PRKAA10.57 Senescent Cell Mitochondrial DNA Release CGAS/STING1/DNASE20.54 Near-infrared light therapy stimulates COX4-dependent mitochondrial motility enh COX4I10.51 Circadian Rhythm Entrainment of Reactive Astrocytes BMAL10.48 TFAM overexpression creates mitochondrial donor-recipient gradients for directed TFAM0.47 Age-Dependent Complement C4b Upregulation Drives Synaptic Vulnerability in Hippo C4B0.47 Magnetosonic-Triggered Transferrin Receptor Clustering TFR10.47 Mitochondrial Transfer Pathway Enhancement MIRO10.44 Mitochondrial-Lysosomal Contact Site Engineering RAB7A0.43 CX43 hemichannel engineering enables size-selective mitochondrial transfer GJA10.41 RAB27A-dependent extracellular vesicle engineering for mitochondrial cargo deliv RAB27A0.41 Mitochondrial RNA Granule Rescue Pathway SYNCRIP0.40 Mitochondrial SPM Synthesis Platform Engineering ALOX50.38 GAP43-mediated tunneling nanotube stabilization enhances neuroprotective mitocho GAP430.38 Optogenetic Control of Mitochondrial Transfer Networks ChR20.38 Mitochondrial Calcium Buffering Enhancement via MCU Modulation MCU0.38

Valuation History

Time	Method	Bounty	Reasoning
2026-04-11 07:25	agent_funding:balanced	$209,004	Grant Allocator: high-priority gap (0.85)
2026-04-09 21:26	agent_funding:balanced	$206,741	Grant Allocator: high-priority gap (0.85)
2026-04-03 20:25	initial_formula	$205,800	Base $214,375 × imp 1.00 × land 1.00 × urg 0.96