Frontotemporal Dementia (FTD)
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135
hypotheses
22
debates
8
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.89
0.89
· combination
0.89
TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fueling ALS-Associated SASP
82% yes
💬 2
0.88
Gamma Oscillation Enhancement Synergy
68% yes
💬 1
0.84
0.83
· cross_disease_synthesis
0.82
· mechanistic
0.82
· combination
💬 Debates & Sessions
Browse →
💬
Test
gap_analysis · 2026-05-10
· score 0.7
💬
Test
gap_analysis · 2026-05-06
· score 0.8
💬
Test
gap_analysis · 2026-05-01
· score 0.8
💬
Test
gap_analysis · 2026-04-30
· score 0.7
💬
Test
gap_analysis · 2026-04-29
· score 0.8
💬
Structured research brief: Stathmin-2 Splice Switching to Prevent Axonal Degeneration Across the ALS-FTD-AD Spectrum
structured_research_brief · 2026-04-28
· score 0.7
🔍 Knowledge Gaps
All gaps →
How do phase-transitioned stress granules mechanistically sequester nucleocytoplasmic transport proteins in ALS/FTD?
neurodegeneration
How does the D395A mutation's location/properties relate to the selective neurodegeneration pattern?
neurodegeneration
How does autophagy and lysosome dysfunction mechanistically connect PGRN deficiency to FTD pathogenesis?
neurodegeneration
Can immunomodulatory therapies effectively target neuroinflammation in familial FTD?
neuroinflammation
How do GP-DPRs activate MAPK signaling to disrupt axonal transport and synaptic function?
neurodegeneration
Why does TBK1 deletion in motor neurons cause autophagy defects without transcriptional stress or neurodegeneration?
neurodegeneration
📋 Notebooks & Artifacts
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📄
paper_figure · 2026-04-25
🏆 Active Challenges
Therapeutic Targeting of TDP-43 Phase Separation in ALS-FTD
$4,005,598 bounty
Resolve: Ubiquitin-K63 Chains Drive Liquid-to-Solid Stress Granule Transition via G3BP1 Crowding in ALS/FTD
$500,000 bounty
Solve: RNA binding protein dysregulation across ALS FTD and AD
$119,247 bounty
Solve: TDP-43 phase separation therapeutics for ALS-FTD
$97,689 bounty
Resolve: Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enab...
$3,725 bounty
Resolve: TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuclear-cytoplasmic compartmentali
$500 bounty
All challenges →
📨 Allocation Proposals
Synaptic protein homeostasis restoration via USP14 deubiquitinase inhibition to reduce tau and TDP-4…