The authors observe that microglial TBK1 deletion causes T cell infiltration specifically in substantia nigra pars reticulata and pallidum, correlating with social deficits. The signaling pathways connecting microglial dysfunction to peripheral immune cell recruitment in these regions remain unexplained. Gap type: unexplained_observation Source paper: ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice. (2025, Nature communications, PMID:40858618)
Landscape Summary: What molecular mechanisms link microglial TBK1 deficiency to T cell infiltration in specific brain regions? is a 0.76 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What molecular mechanisms link microglial TBK1 deficiency to T cell infiltration in specific brain regions? — INVOKE-2 (completed)
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