What molecular mechanisms link microglial TBK1 deficiency to T cell infiltration in specific brain regions?

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The authors observe that microglial TBK1 deletion causes T cell infiltration specifically in substantia nigra pars reticulata and pallidum, correlating with social deficits. The signaling pathways connecting microglial dysfunction to peripheral immune cell recruitment in these regions remain unexplained. Gap type: unexplained_observation Source paper: ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice. (2025, Nature communications, PMID:40858618)

Priority: 0.76 Domain: neuroinflammation Hypotheses: 0
📊 Landscape Analysis

Landscape Summary: What molecular mechanisms link microglial TBK1 deficiency to T cell infiltration in specific brain regions? is a 0.76 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

What molecular mechanisms link microglial TBK1 deficiency to T cell infiltration in specific brain regions? — INVOKE-2 (completed)

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0.000
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🌊 Knowledge Graph Connections

activates (16)

TBK1IRF3TBK1DNATBK1Immune ResponseTBK1CGAS-STINGTBK1STING
▸ Show 11 more

associated with (5)

TBK1AlsTBK1Amyotrophic Lateral SclerosisTBK1Frontotemporal DementiaTBK1frontotemporal dementiaTBK1OPTN

binds (2)

TBK1OptineurinTBK1CLASS III PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX I

causes (3)

TBK1Motoneuron pathologyTBK1alsTBK1Autophagolysosomal dysfunction

contributes to (1)

TBK1Autophagolysosomal Dysfunction

describes (1)

genes-tbak1TBK1

does not cause (1)

TBK1neuroinflammation

encodes (1)

TBK1TBK1

implicated in (1)

TBK1amyotrophic lateral sclerosis

increases risk (1)

TBK1als

inhibits (2)

amlexanoxTBK1FIP200TBK1

interacts with (3)

AUTOPHAGYTBK1TBK1AlsZBP1TBK1

linked to (1)

genes-tbk1TBK1

phosphorylates (3)

TBK1Sqstm1TBK1p62TBK1SQSTM1

regulates (5)

TBK1mitophagyTBK1autophagy pathwayTBK1macroautophagyTBK1selective autophagyTBK1innate immunity

risk factor for (4)

TBK1amyotrophic lateral sclerosisTBK1ALSTBK1ALS/FTDTBK1FTD
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